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. 2024 Jan 3;84(1):43-47.
doi: 10.1055/a-2205-1725. eCollection 2024 Jan.

Statement of the Obstetrics and Prenatal Medicine Working Group (AGG - Preterm Birth Section) on "Outpatient Management for Pregnant Women with Preterm Premature Rupture of Membranes (PPROM)"

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Statement of the Obstetrics and Prenatal Medicine Working Group (AGG - Preterm Birth Section) on "Outpatient Management for Pregnant Women with Preterm Premature Rupture of Membranes (PPROM)"

Mirjam Kunze et al. Geburtshilfe Frauenheilkd. .

Abstract

Preterm premature rupture of membranes (PPROM) is one of the leading causes of perinatal morbidity and mortality. After a PPROM, more than 50% of pregnant women are delivered within 7 days. Fetal and maternal risks are primarily due to infection and inflammation, placental abruption, umbilical cord complications and preterm birth. Standard care usually consists of an expectant approach. Management includes the administration of antenatal steroids and antibiotic therapy. Patients with PPROM require close monitoring. The management of pregnant women with PPROM (inpatient vs. outpatient) is still the subject of controversial debate. The international guidelines also do not offer a clear stance. The statement presented here discusses the current state of knowledge.

Keywords: outpatient care; preterm birth; preterm premature rupture of membranes.

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Conflict of interest statement

Conflict of Interest The authors declare that they have no conflict of interest.

References

    1. Mercer BM, Miodovnik M, Thurnau GR et al.Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. JAMA. 1997;278:989–995. - PubMed
    1. Chien E, Mercer BM. Preterm Premature Rupture of the Membranes in the Twenty-First Century. Obstet Gynecol Clin North Am. 2020;47:xiii–xiv. doi: 10.1016/j.ogc.2020.09.002. - DOI - PubMed
    1. Carlan SJ, OʼBrien WF, Parsons MT et al.Preterm premature rupture of membranes: a randomized study of home versus hospital management. Obstet Gynecol. 1993;81:61–64. - PubMed
    1. Ryan G, Oskamp M, Seaward P et al.Randomized controlled trial of inpatient vs. outpatient management of PPROM. Am J Obstet Gynecol. 1999;180:S95.
    1. Abou El Senoun G, Dowswell T, Mousa HA. Planned home versus hospital care for preterm prelabour rupture of the membranes (PPROM) prior to 37 weeksʼ gestation. Cochrane Database Syst Rev. 2014;(04):CD008053. doi: 10.1002/14651858.CD008053.pub3. - DOI - PMC - PubMed