Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan;29(1):2300703.
doi: 10.2807/1560-7917.ES.2024.29.1.2300703.

Early COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023

C Henri van Werkhoven  1   2 , Anne-Wil Valk  1 , Bente Smagge  1 , Hester E de Melker  1 , Mirjam J Knol  1 , Susan Jm Hahné  1 , Susan van den Hof  1 , Brechje de Gier  1
Affiliations

Early COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023

C Henri van Werkhoven et al. Euro Surveill. 2024 Jan.

Abstract

We present early vaccine effectiveness (VE) estimates of the 2023 seasonal COVID-19 XBB.1.5 vaccine against COVID-19 hospitalisation and admission to an intensive care unit (ICU) in previously vaccinated adults ≥ 60 years in the Netherlands. We compared vaccination status of 2,050 hospitalisations including 92 ICU admissions with age group-, sex-, region- and date-specific population vaccination coverage between 9 October and 5 December 2023. VE against hospitalisation was 70.7% (95% CI: 66.6-74.3), VE against ICU admission was 73.3% (95% CI: 42.2-87.6).

Keywords: COVID-19; COVID-19 vaccination; Vaccine effectiveness.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: CHvW reports financial and non-financial research support from DaVolterrra and bioMérieux; financial research support from LimmaTech; consultancy fees from MSD and Sanofi-Pasteur (all payments to the University Medical Centre Utrecht). Other authors have nothing to report.

Figures

Figure 1
Figure 1
COVID-19 hospitalisations included in the analysis, the Netherlands, 9 October–5 December 2023 (n = 2,050)
Figure 2
Figure 2
7-day moving average of the proportion of seasonal vaccinees among hospitalised cases and among the population ≥ 60 years eligible for seasonal COVID-19 vaccination on 25 September 2023, the Netherlands, 9 October–5 December 2023 (n = 4,184,231)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. National Institute for Public Health and the Environment (RIVM). Deelname COVID-19-vaccinatie in Nederland (19 december 2023) [Uptake of COVID-19 vaccination in the Netherlands (19 December 2023)]. Bilthoven: RIVM; 2023. [Dutch]. Available from: https://www.rivm.nl/corona/actueel/vaccinatiecijfers/update-deelname-cov...
    1. Government of the Netherlands. Coronavirus Dashboard. Virus particles in wastewater. The Hague: Rijksoverheid. [Accessed: 20 Dec 2023]. Available from: https://coronadashboard.government.nl/landelijk/rioolwater
    1. Government of the Netherlands. Coronavirus Dashboard. View on the hospitals. The Hague: Rijksoverheid. [Accessed: 12 Dec 2023]. Available from: https://coronadashboard.government.nl/landelijk/ziekenhuizen-in-beeld
    1. Van Werkhoven CH, De Gier B, McDonald SA, De Melker HE, Hahne SJM, Van den Hof S, et al. Information bias of vaccine effectiveness estimation due to informed consent for national registration of COVID-19 vaccination: estimation and correction using a data augmentation model. medRxiv. 2023:2023.05.23.23290384 .10.1101/2023.05.23.23290384 - DOI
    1. National Institute for Public Health and the Environment (RIVM). Uitvoeringsrichtlijn COVID-19-vaccinatie, versie 5.1 (8 december 2023). [COVID-19 guideline version 5.1 (8 December 2023)]. Bilthoven: RIVM; 2023. Dutch. Available from: https://lci.rivm.nl/richtlijnen/covid-19-vaccinatie

LinkOut - more resources