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. 2024 Jan;29(1):2300703.
doi: 10.2807/1560-7917.ES.2024.29.1.2300703.

Early COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023

C Henri van Werkhoven  1   2 , Anne-Wil Valk  1 , Bente Smagge  1 , Hester E de Melker  1 , Mirjam J Knol  1 , Susan Jm Hahné  1 , Susan van den Hof  1 , Brechje de Gier  1
Affiliations

Early COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023

C Henri van Werkhoven et al. Euro Surveill. 2024 Jan.

Abstract

We present early vaccine effectiveness (VE) estimates of the 2023 seasonal COVID-19 XBB.1.5 vaccine against COVID-19 hospitalisation and admission to an intensive care unit (ICU) in previously vaccinated adults ≥ 60 years in the Netherlands. We compared vaccination status of 2,050 hospitalisations including 92 ICU admissions with age group-, sex-, region- and date-specific population vaccination coverage between 9 October and 5 December 2023. VE against hospitalisation was 70.7% (95% CI: 66.6-74.3), VE against ICU admission was 73.3% (95% CI: 42.2-87.6).

Keywords: COVID-19; COVID-19 vaccination; Vaccine effectiveness.

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Conflict of interest statement

Conflict of interest: CHvW reports financial and non-financial research support from DaVolterrra and bioMérieux; financial research support from LimmaTech; consultancy fees from MSD and Sanofi-Pasteur (all payments to the University Medical Centre Utrecht). Other authors have nothing to report.

Figures

Figure 1
Figure 1
COVID-19 hospitalisations included in the analysis, the Netherlands, 9 October–5 December 2023 (n = 2,050)
Figure 2
Figure 2
7-day moving average of the proportion of seasonal vaccinees among hospitalised cases and among the population ≥ 60 years eligible for seasonal COVID-19 vaccination on 25 September 2023, the Netherlands, 9 October–5 December 2023 (n = 4,184,231)
See this image and copyright information in PMC

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