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. 2024 Jan;20(1):46-49.
doi: 10.3988/jcn.2022.0340.

Normative Values for Serum Neurofilament Light Chain in US Adults

Thomas A Beltran  1
Affiliations

Normative Values for Serum Neurofilament Light Chain in US Adults

Thomas A Beltran. J Clin Neurol. 2024 Jan.

Abstract

Background and purpose: Neurofilament light chain (NfL) levels serve as a marker of neuroaxonal injury and can be measured in both cerebrospinal fluid and serum. Although serum NfL (sNfL) levels have been shown to increase with the progression of various neurological conditions, normative values for healthy individuals have not yet been established. This study was undertaken to determine age-specific normative values for sNfL and evaluate the associations between sNfL and sociodemographic characteristics.

Methods: A retrospective analysis was conducted using population-based data collected by the National Health and Nutrition Examination Survey between 2013 and 2014. The sera of 2071 adult participants were collected. General linear models were used to examine the associations between sNfL levels and sample characteristics.

Results: The data analysis revealed a significant positive association between age and sNfL levels (p<0.001). Sex was also associated with sNfL levels (p=0.04) after controlling for age. The mean sNfL levels for males and females were 17.99 pg/mL (95% confidence interval [CI]=15.43-20.17) and 15.78 pg/mL (95% CI=13.00-18.55) respectively, after controlling for age.

Conclusions: These results suggest that sNfL levels increase with age and are affected by sex. The findings of this study provide a useful baseline for comparing sNfL levels in clinical practice and future research.

Keywords: NHANES; biological assay; biomarker; neurofilament; neuron; normative; serum neurofilament light chain.

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Conflict of interest statement

The author has no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1. Mean serum neurofilament light chain by age.
See this image and copyright information in PMC

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