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Comparative Study
. 2024 Jun;72(6):408-416.
doi: 10.1007/s11748-023-01999-4. Epub 2024 Jan 5.

Single lung transplantation using a lung graft from a donor whose contralateral lung is not suitable for lung transplantation

Hisashi Oishi  1 , Takashi Hirama  2 , Tatsuaki Watanabe  2 , Yui Watanabe  2 , Hiromichi Niikawa  2 , Masafumi Noda  2 , Takaya Suzuki  2 , Hirotsugu Notsuda  2 , Yoshinori Okada  2
Affiliations
Comparative Study

Single lung transplantation using a lung graft from a donor whose contralateral lung is not suitable for lung transplantation

Hisashi Oishi et al. Gen Thorac Cardiovasc Surg. 2024 Jun.

Abstract

Objective: This study aims to compare the post-transplant survival of untwinned single lung transplantation (SLT) to twinned SLT. In untwinned SLT, the contralateral lung is judged unsuitable for transplantation and might affect the lung graft within the donor body and recipient survival after SLT.

Methods: A retrospective analysis was conducted on 84 SLT recipients at our center, divided into untwinned SLT and twinned SLT groups. The demographics of donors and recipients, surgical characteristics, complications, mortality, and survival rates were compared.

Results: There were no significant differences in recipient and donor demographics between the two groups. Surgical characteristics showed no significant differences. Microbiological findings of the transplanted lungs indicated a low incidence of positive cultures in both groups. 3-month to 1-year mortality and overall survival rates were comparable between the two groups.

Conclusion: At our institution, both untwinned and twinned SLT procedures exhibited excellent survival rates without significant differences between the two procedures. The favorable outcomes observed may be associated with the strategic advantages of Japan's MC system and the diligent management of marginal donor lungs although this requires further investigation to elucidate the specific contributory factors.

Keywords: Lung transplantation; Marginal donor; Single lung transplantation; Twinned single lung transplantation.

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References

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