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Review
. 2024 Jan 5;103(1):e36278.
doi: 10.1097/MD.0000000000036278.

Adjuvant trastuzumab for triple-positive breast cancer with chronic renal failure: A case report and review of literature

Wen En  1 , Yuming Long
Affiliations
Review

Adjuvant trastuzumab for triple-positive breast cancer with chronic renal failure: A case report and review of literature

Wen En et al. Medicine (Baltimore). .

Abstract

Rationale: Although the occurrence of combined renal insufficiency among patients with breast cancer is even rarer, it poses a significant challenge in the treatment of these patients. Treating such patients often requires both targeted and endocrine therapies. However, oncologists lack evidence-based guidelines for managing renal function in patients with renal insufficiency.

Patients concern: A 56-year-old menopausal female with a history of renal failure was diagnosed with triple-positive breast cancer and administered endocrine therapy and targeted therapy associated with hemodialysis after surgery.

Outcomes: Under the premise of regular dialysis, the patient successfully completed endocrine therapy and targeted therapy for 1 year.

Discussion: Patients with advanced triple-positive breast cancer, including those undergoing hemodialysis, require a combination of anti-human epidermal growth factor receptor-2 and endocrine therapies, The side effects of these 2 treatment methods are worth considering in patients with renal insufficiency.

Conclusion: We report a case of triple-positive breast cancer in a patient undergoing hemodialysis. There was no difference in the treatment approach between patients with and without normal renal function.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Pathological biopsy hematoxylin-eosin staining.
Figure 2.
Figure 2.
Pathological biopsy hematoxylin-eosin staining.
Figure 3.
Figure 3.
HER-2 (+++) immunohistochemical. HER-2 = human epidermal growth factor receptor-2.
See this image and copyright information in PMC

References

    1. Bozikas A, Kiriakoutzik I, Petrou I, et al. . Aiming for the optimal bicarbonate prescription for maintenance hemodialysis therapy in end-stage renal disease. Hemodialysis Int Symp Home Hemodialysis. 2019. - PubMed
    1. Breast Cancer Expert Committee, Beijing Breast Disease Prevention and Control Society Health Management Professional Committee. Chinese guide to follow-up and health management of breast cancer (2022 edition). Chinese J Oncol. 2022;44:28.
    1. Wu W, Cheng S, Deng H, et al. . Impact of breast cancer subtype defined by immunohistochemistry hormone receptor and HER2 status on the incidence of immediate postmastectomy reconstruction. Medicine (Baltimore). 2016;95:e2547. - PMC - PubMed
    1. National Comprehensive Cancer Network. (NCCN). Clinical practice guidelines in oncology. Breast Cancer. 2022. Version 1.
    1. Meng D, Qu H, Yue W, et al. . The treatment strategies of breast cancer in patients with renal dysfunction. Chinese German J Clin Oncol. 2010;09:594–6.