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Comment
. 2024 Jan 4;31(1):1-2.
doi: 10.1016/j.stem.2023.12.010.

The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids

Shree Bose  1 , Xiling Shen  2
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The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids

Shree Bose et al. Cell Stem Cell. .
Free article

Abstract

Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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