Improving cellular diversity in human cerebellar organoids

Marilyn Steyert¹, Tomasz Nowakowski²

Affiliations

¹ Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
² Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: tomasz.nowakowski@ucsf.edu.

PMID: 38181748
DOI: 10.1016/j.stem.2023.12.007

Free article

Improving cellular diversity in human cerebellar organoids

Marilyn Steyert et al. Cell Stem Cell. 2024.

Free article

. 2024 Jan 4;31(1):3-4.

doi: 10.1016/j.stem.2023.12.007.

Authors

Marilyn Steyert¹, Tomasz Nowakowski²

Affiliations

¹ Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
² Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: tomasz.nowakowski@ucsf.edu.

PMID: 38181748
DOI: 10.1016/j.stem.2023.12.007

Abstract

The developing human cerebellum has a greater diversity of progenitor types than that of the mouse, necessitating a human-based model for studying cerebellar development and disease. Atamian et al.¹ developed a 3D organoid model of cerebellar development, which recapitulates many cell types found in the developing human cerebellum, including Purkinje-neuron-like cells.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment in

Human cerebellar organoids with functional Purkinje cells.
Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, Paul S, Tedeschi N, Taylor R, Coba MP, Samarasinghe R, Lois C, Quadrato G. Atamian A, et al. Cell Stem Cell. 2024 Jan 4;31(1):39-51.e6. doi: 10.1016/j.stem.2023.11.013. Cell Stem Cell. 2024. PMID: 38181749 Free PMC article.

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Improving cellular diversity in human cerebellar organoids

Affiliations

Improving cellular diversity in human cerebellar organoids

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

MeSH terms

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Full Text Sources