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Comment
. 2024 Jan 4;84(1):17-19.
doi: 10.1016/j.molcel.2023.12.009.

Lysosome identity crisis: Phosphoinositides and mTORC1 negotiate lysosomal behavior

Mélanie Mansat  1 , Roberto J Botelho  2
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Free article
Comment

Lysosome identity crisis: Phosphoinositides and mTORC1 negotiate lysosomal behavior

Mélanie Mansat et al. Mol Cell. .
Free article

Abstract

Ebner et al.1 discovered a nutrient-dependent molecular feedback circuit that employs mTORC1, lipid kinases, and phosphatases to generate phosphatidylinositol-3-phosphate [PI(3)P] or phosphatidylinositol-4-phosphate [PI(4)P] in a mutually exclusive manner on lysosomes, which respectively convert lysosomes into organelles that support anabolism or catabolism.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Nutrient-regulated control of lysosome function by signaling lipid conversion.
    Ebner M, Puchkov D, López-Ortega O, Muthukottiappan P, Su Y, Schmied C, Zillmann S, Nikonenko I, Koddebusch J, Dornan GL, Lucht MT, Koka V, Jang W, Koch PA, Wallroth A, Lehmann M, Brügger B, Pende M, Winter D, Haucke V. Ebner M, et al. Cell. 2023 Nov 22;186(24):5328-5346.e26. doi: 10.1016/j.cell.2023.09.027. Epub 2023 Oct 25. Cell. 2023. PMID: 37883971

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