A beneficial response of fetal wound healing gone bad in the bile duct: The overarching cause of biliary atresia?

Affiliations

¹ Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
² Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: u.h.beuers@amsterdamumc.nl.

Editorial

David C Trampert et al. J Hepatol. 2024 Mar.

. 2024 Mar;80(3):387-389.

doi: 10.1016/j.jhep.2023.12.018. Epub 2024 Jan 4.

¹ Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands.
² Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism (AGEM), Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: u.h.beuers@amsterdamumc.nl.

No abstract available

Keywords: Bile viscosity; cholangiocytes; cilia; collagen; extracellular matrix; glycocalyx; hyaluronic acid; peribiliary glands.

Comment on

A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia.
de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, Erxleben D, Rivas F, Hall AR, Furth EE, Naji A, Liu C, Dhand A, Burdick JA, Davey MG, Flake AW, Porte RJ, Russo PA, Gaynor JW, Wells RG. de Jong IEM, et al. J Hepatol. 2023 Dec;79(6):1396-1407. doi: 10.1016/j.jhep.2023.08.010. Epub 2023 Aug 21. J Hepatol. 2023. PMID: 37611641 Free PMC article.