Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jan 5;29(1):24.
doi: 10.1186/s40001-023-01613-6.

28-day perioperative pediatric mortality and its predictors in a tertiary teaching hospital in Ethiopia: a prospective cohort study

Misganew Terefe Molla  1 , Nebiyu Shitaye Anley  2 , Bekalu Wubshet Zewdie  3 , Amanuel Sisay Endeshaw  4 , Fantahun Tarekegn Kumie  4
Affiliations

28-day perioperative pediatric mortality and its predictors in a tertiary teaching hospital in Ethiopia: a prospective cohort study

Misganew Terefe Molla et al. Eur J Med Res. .

Abstract

Background: Perioperative pediatric mortality is significantly higher in low-resource countries due to a scarcity of well-trained professionals and a lack of well-equipped pediatric perioperative services. There has been little research on pediatric mortality in low-income countries. Therefore, this study aimed to assess the incidence of perioperative pediatric mortality and its predictors in 28-day follow-up.

Methods: The data were collected using REDCap, an electronic data collection tool, between June 01, 2019 and July 01, 2021. This study includes pediatric patients aged 0 to 17 years who underwent surgery in Tibebe Ghion Specialized Hospital over 28 days with a total of 1171 patients. STATA version 17 software was used for data analysis. Log-rank tests were fitted to explore survival differences. After bivariable and multivariable Cox regression analysis, an Adjusted Hazard Ratio (AHR) with a 95% Confidence Interval (CI) was reported to declare the strength of association and statistical significance.

Results: There were 35 deaths in the cohort of 1171 pediatric patients. Twenty of the deaths were in neonates. The overall perioperative mortality among pediatric patients was 2.99%, with an incidence rate of 1.11 deaths per 1000 person day observation (95% CI 0.79, 1.54). The neonatal age group had an AHR = 9.59, 95% CI 3.77, 24.3), transfusion had an AHR = 2.6, 95% CI 1.11, 6.09), and the America Society of Anesthesiology physical status classification III and above had an AHR = 4.39, 95% CI 1.61, 11.9 were found the significant predictors of perioperative pediatric mortality.

Conclusions: In this study, the perioperative mortality of pediatric patients was high in the 28-day follow-up. Neonatal age, transfusion, and America Society of Anesthesiology physical status III and above were significant predictors of pediatric mortality. Therefore, perioperative surgical teams should give special attention to neonates, the America Society of Anesthesiology physical status III and above, and transfusion to reduce pediatric mortality.

Keywords: Ethiopia; Mortality; Pediatric; Perioperative; Surgery.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study population profile
Fig. 2
Fig. 2
Frequency of deaths in each postoperative time interval
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Funk LM, Weiser TG, Berry WR, Lipsitz SR, Merry AF, Enright AC, et al. Global operating theatre distribution and pulse oximetry supply: an estimation from reported data. Lancet. 2010;376(9746):1055–1061. doi: 10.1016/S0140-6736(10)60392-3. - DOI - PubMed
    1. Weiser TG, Regenbogen SE, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, et al. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet. 2008;372(9633):139–144. doi: 10.1016/S0140-6736(08)60878-8. - DOI - PubMed
    1. Bickler SW, Rode H. Surgical services for children in developing countries. Bull World Health Organ. 2002;80(10):829–835. - PMC - PubMed
    1. Adudu P. Anesthetic equipment, facilities and services available for pediatric anesthesia in Nigeria. Niger J Clin Pract. 2012;15(1):75. doi: 10.4103/1119-3077.94103. - DOI - PubMed
    1. Hodges S, Mijumbi C, Okello M, McCormick B, Walker I, Wilson IH. Anaesthesia services in developing countries: defining the problems. Anaesthesia. 2007;62(1):4–11. doi: 10.1111/j.1365-2044.2006.04907.x. - DOI - PubMed

LinkOut - more resources