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. 2024 Apr;15(2):423-434.
doi: 10.1007/s41999-023-00911-w. Epub 2024 Jan 6.

Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters

Merve Hafızoğlu  1 , Funda Eren  2 , Salim Neşelioğlu  2 , Zeynep Şahiner  3 , Didem Karaduman  3 , Cansu Atbaş  3 , Ayşe Dikmeer  3 , İbrahim İleri  3 , Cafer Balcı  3 , Burcu Balam Doğu  3 , Mustafa Cankurtaran  3 , Özcan Erel  2 , Meltem Gülhan Halil  3
Affiliations

Physical frailty is related to oxidative stress through thiol/disulfide homeostasis parameters

Merve Hafızoğlu et al. Eur Geriatr Med. 2024 Apr.

Abstract

Aim: To evaluate relationship between frailty and oxidative stress through thiol/disulfide homeostasis parameters [Native thiol (NT), total thiol (TT), and disulfide levels (D), disulfide-native thiol (D/NT), disulfide-total thiol (D/TT), native thiol-total thiol (NT/TT) ratios, and ischemia-modified albumin levels (IMA)].

Materials and methods: In total, 139 community-dwelling older adults were included. The frailty status, defined by the FRIED frailty index (FFI) and Clinical Frailty Scale (CFS), and comprehensive geriatric assessment results compared with thiol/disulfide homeostasis parameters and ischemia-modified albumin levels.

Results: NT and TT levels were significantly lower in the frail group (respectively; p = 0.014, p = 0.020). The FFI scores were correlated with the levels of NT, TT, D/NT, D/TT, and NT/TT (respectively; r = - 0.25, r = - 0.24, r = 0.17, r = 0.17, r = - 0.17). The significant correlation could not be retained with the CFS scores. In ROC analysis, the AUC for NT was calculated as 0.639 in diagnosing frailty according to the FFI (95% CI 0.542-0.737), AUC was 0.638 for TT (95% CI 0.540-0.735), and AUC was 0.610 for NT/TT (95% CI 0.511-0.780). The AUC was calculated as 0.610 for both D/NT and D/TT in diagnosing physical frailty (95% CI 0.511-0.708).

Conclusion: Thiol/disulfide homeostasis parameters can be a potential biomarker in diagnosing physical frailty. However, further studies are needed for diagnosing frailty defined with cumulative deficit models.

Keywords: Anti-oxidant; Frailty; Older patients; Oxidative stress.

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