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Review
. 2024 Feb:143:107091.
doi: 10.1016/j.bioorg.2023.107091. Epub 2024 Jan 4.

C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018-2023)

Mohamed H Helal  1 , Medhat E Owda  2 , Amal T Mogharbel  3 , Ali Hamzah Alessa  3 , Noha Omer  3 , Mahmoud A Abdelaziz  3 , Islam Ibrahim  4 , Essam M Eliwa  5
Affiliations
Review

C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018-2023)

Mohamed H Helal et al. Bioorg Chem. 2024 Feb.

Abstract

This scientific review documents the recent progress of C3-spirooxindoles chemistry (synthesis and reaction mechanism) and their bioactivities, focusing on the promising results as well as highlighting the biological mechanism via the reported molecular docking findings of the most bioactive derivatives. C3-Spirooxindoles are attractive bioactive agents and have been found in a variety of natural compounds, including alkaloids. They are widely investigated in the field of medicinal chemistry and play a key role in medication development, such as antivirals, anticancer agents, antimicrobials, etc. Regarding organic synthesis, several traditional and advanced strategies have been reported, particularly those that started with isatin derivatives.

Keywords: Bioactivity; Chemical synthesis; Molecular docking; Reaction mechanism; Spirooxindole.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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