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Review
. 2024 Feb:143:107093.
doi: 10.1016/j.bioorg.2023.107093. Epub 2024 Jan 4.

Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation

Huawei Lv  1 , Wen-Jing Li  1 , Ping Xu  1 , Jia-Gui Tang  1 , Yu Zheng  1 , Yu Wan  1 , Yan Lin  2 , Hong Wang  3 , Xing-Nuo Li  4
Affiliations
Review

Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation

Huawei Lv et al. Bioorg Chem. 2024 Feb.

Abstract

Fungi are microorganisms with biosynthetic potential that are capable of producing a wide range of chemically diverse and biologically interesting small molecules. Chemical epigenetic manipulation has been increasingly explored as a simple and powerful tool to induce the production of additional microbial secondary metabolites in fungi. This review focuses on chemical epigenetic manipulation in fungi and summarizes 379 epigenetic manipulation products discovered from 2008 to 2022 to promote the discovery of their medicinal value.

Keywords: Chemical epigenetic manipulation; Fungi; Secondary metabolites.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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