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Comparative Study
. 1987 Feb;23(2):129-33.
doi: 10.1007/BF02623593.

The comparative study of cardiovascular toxins utilizing a sensitive indicator of sublethal toxic injury

R H Hysmith, T K Welch, P J Boor
Comparative Study

The comparative study of cardiovascular toxins utilizing a sensitive indicator of sublethal toxic injury

R H Hysmith et al. In Vitro Cell Dev Biol. 1987 Feb.

Abstract

This study measures the inhibition of [3H]uridine uptake by smooth muscle cells to determine sublethal toxic injury by the cardiovascular toxins, allylamine, isoproterenol, and beta-aminopropionitrile. The exposure period or the concentration of toxin which inhibited 30% of [3H]uridine uptake by smooth muscle cells could be utilized as an endpoint for ranking toxicity. Cytotoxicity of the three toxins to smooth muscle cells were ranked as: allylamine greater than isoproterenol greater than beta-aminopropionitrile. Recovery of cells utilizing [3H]uridine uptake inhibition as a method for assessing comparative cytotoxicity and for screening of agents potentially injurious to vascular cells.

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References

    1. In Vitro Cell Dev Biol. 1985 Sep;21(9):495-504 - PubMed
    1. Am J Pathol. 1972 Feb;66(2):225-40 - PubMed
    1. Lab Invest. 1982 Jul;47(1):76-86 - PubMed
    1. Am J Pathol. 1985 Oct;121(1):39-54 - PubMed
    1. Infect Immun. 1975 Apr;11(4):640-8 - PubMed

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