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Comment
. 2024 Jan 7;19(1):3.
doi: 10.1186/s13024-023-00681-w.

Blood platelet factor 4: the elixir of brain rejuvenation

José M Izquierdo  1
Affiliations
Comment

Blood platelet factor 4: the elixir of brain rejuvenation

José M Izquierdo. Mol Neurodegener. .
No abstract available

Keywords: Brain rejuvenation; Neuroinflammation; Platelet factor 4.

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Overview of brain aging and rejuvenation in mice in a PF4-dependent manner. Reduced or increased levels of PF4 (blood platelet factor 4) lead to aging-associated neurodegeneration and brain rejuvenation in mice and potentially in humans, respectively. Administration of klotho, physical exercise, caloric restriction and/or senolytics increase PF4 levels, with beneficial effects on aging-associated neurodegeneration and brain rejuvenation
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