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. 2024 Mar 26;12(2):142-153.
doi: 10.1093/sxmrev/qead052.

Psychosocial interventions to improve sexual functioning in women with cancer: a systematic review of randomized controlled trials

Lauren M Carney  1 , Julie B Schnur  1 , Orly Morgan  2 , Christine Hyun  1 , Zachary E Magin  3 , Lily Martin  4 , Guy H Montgomery  1
Affiliations

Psychosocial interventions to improve sexual functioning in women with cancer: a systematic review of randomized controlled trials

Lauren M Carney et al. Sex Med Rev. .

Abstract

Introduction: Many women with cancer struggle with sexual side effects during and after treatment. Although preliminary evidence indicates that psychosocial interventions may be efficacious in improving sexual functioning for women with cancer, no systematic review has summarized the state of the science in this area.

Objectives: The primary goal of this review was to narratively synthesize the results of randomized controlled trials (RCTs) testing the efficacy of psychosocial interventions to address sexual dysfunction in women with cancer. A secondary goal was to describe the diversity of the included samples (ie, racial/ethnic and sexual minority).

Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic review was conducted examining RCTs of psychosocial interventions to improve sexual functioning for women with cancer. Articles were identified using MEDLINE, Embase, PsycINFO, and Cochrane CENTRAL. Two reviewers independently assessed each article for inclusion, with a third to resolve discrepancies.

Results: Seventeen studies were included in the review, 12 of which provided sufficient information to calculate effect sizes. Ten of the 12 studies primarily aimed to improve sexual functioning, all of which demonstrated positive effects on at least 1 outcome of sexual functioning. In the 2 RCTs of psychosocial interventions in which sexual function was a secondary aim, effects were negligible (ds = -0.04 and -0.15). Commonalities among the studies with large effect sizes were that they included education, mindfulness/acceptance, and communication/relationship skills as intervention components. Of note, there was an overall lack of sample diversity across studies, and most studies failed to report the race/ethnicity or sexual orientation of the participants.

Conclusion: Results support interventions targeting sexual functioning outcomes for women with cancer and suggest that multimodal interventions including education, mindfulness/acceptance, and communication/relationship skills may be most effective. Future research should also focus on examining the efficacy and potential adaptations of extant sexual functioning interventions for underrepresented groups.

Keywords: cancer; education; mindfulness; psychological; psychosocial; sexual functioning; systematic review.

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Conflict of interest statement

None reported.

Figures

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Figure 1
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow chart.
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References

    1. Nappi RE, Cucinella L, Martella S, Rossi M, Tiranini L, Martini E. Female sexual dysfunction (FSD): prevalence and impact on quality of life (QoL). Maturitas. 2016;94:87–91. 10.1016/j.maturitas.2016.09.013. - DOI - PubMed
    1. Grover S, Hill-Kayser CE, Vachani C, Hampshire MK, DiLullo GA, Metz JM. Patient reported late effects of gynecological cancer treatment. Gynecol Oncol. 2012;124(3):399–403. - PubMed
    1. Maiorino MI, Chiodini P, Bellastella G, Giugliano D, Esposito K. Sexual dysfunction in women with cancer: a systematic review with meta-analysis of studies using the female sexual function index. Endocrine. 2016;54(2):329–341. - PubMed
    1. Fischer OJ, Marguerie M, Brotto LA. Sexual function, quality of life, and experiences of women with ovarian cancer: a mixed-methods study. Sex Med. 2019;7(4):530–539. - PMC - PubMed
    1. Tarkowska M, Głowacka-Mrotek I, Nowikiewicz T, et al. Sexual functioning and self-esteem in women after mastectomy – a single-centre, non-randomised, cross-sectional study. Contemp Oncol Onkol. 2020;24(2):106–111. - PMC - PubMed

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