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. 2024 Jan 1;52(1):24-37.
doi: 10.15586/aei.v52i1.958. eCollection 2024.

Mexican consensus on cow's milk protein allergy

Ramírez Mayans Jaime Alfonso  1 , Ignorosa Arellano Karen Rubí  2 , Toro Monjaraz Erick Manuel  1 , Cervantes Bustamante Roberto  1 , Ruiz Castillo Marlene Alejandra  3 , Medina Vera Isabel de Jesús  4 , Ayala Germán Ana Gabriela  5 , Bacarreza Nogales Dante Vladimir  6 , Casas Guzik Lucía  7 , Chávez Barrera José Antonio  8 , Díaz Madero Sergio  9 , Flores Fong Laura Esther  10 , Galaz Pantoja Méndez Manuel Enrique  11 , Gris Calvo Judith Ileana  12 , Huerta Hernández Rosa Elena  13 , Limón Rojas Ana Elena  14 , Macías Avilés Héctor  15 , Méndez Nieto Carlos  16 , Ortega Martell José Antonio  13 , Oyervides García Carlos Iván  17 , Peña Vélez Rubén  18 , Reynés Manzur José Nicolás  19 , Saez de Ocariz Gutiérrez María Del Mar  20 , Sagols Méndez Gerardo  21 , Uriquidi Rivera Martha Eugenia  22 , Worona Dibner Liliana  23 , Wakida Kusunoki Guillermo Hideo  24 , Vandenplas Yvan  25
Affiliations

Mexican consensus on cow's milk protein allergy

Ramírez Mayans Jaime Alfonso et al. Allergol Immunopathol (Madr). .

Abstract

Background: The aim of this study is to present the current views of a diverse group of experts on the diagnosis and treatment of Cow's Milk Protein Allergy (CMPA) in children under 2 years of age in Mexico.

Material and methods: The study, led by a scientific committee of five experts in CMPA, was divided into six phases, including a modified Delphi process. A total of 20 panelists, all of whom were pediatric specialists, participated in administering a comprehensive 38-item questionnaire. The questionnaire was divided into two blocks: Diagnosis and Treatment (20 items each).

Results: Consensus was reached on all the proposed items, with an agreement rate of over 70% for each of them. As a result, a diagnostic and treatment algorithm was developed that emphasized the reduction of unnecessary diagnostic studies and encouraged breastfeeding whenever possible. In cases where breast milk is not available, appropriate use of hypoallergenic formulas was recommended. In addition, recommendations on treatment duration and gradual reintroduction of cow's milk protein were provided.

Conclusions: The recommendations endorsed by 20 Mexican pediatricians through this study are applicable to everyday clinical practice, thereby enhancing the diagnosis and treatment of children under 2 years of age with CMPA. This, in turn, will foster improved health outcomes and optimize the utilization of healthcare resources.

Keywords: Consensus; Cow’s Milk Protein Allergy; Delphi; Hypoallergenic Formulas; Tolerance.

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Conflict of interest statement

All authors declare that they have no conflicts of interest.

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