Successful prophylaxis of ESBL Enterobacteriaceae repetitive urinary tract infections with subcutaneous temocillin: a case report

Abstract

Objectives: Temocillin is an antibiotic belonging to the β-lactam family, introduced in 1988 but soon forgotten because of its narrow spectrum. Recently, it has been repurposed for its effectiveness against ESBL Enterobacteriaceae, and represents an alternative of choice to carbapenems due to its limited impact on the microbiota.

Patient: We present here a successful case of antibiotic prophylaxis of recurrent ESBL urinary tract infections with subcutaneously administered temocillin.

Conclusions: Temocillin is rarely administered subcutaneously and even more rarely in prophylactic situations. However, its tolerance profile and low impact on the microbiota should help reconsideration of its use in particular cases like this one.

Figure 1.

Two years of infections in our 51-year-old patient. The upper part lists infections with ESBL-producing organisms; the lower part lists those with non-ESBL-producing organisms. The left part lists infections 1 year before the introduction of temocillin; the right part lists those 1 year after the introduction of temocillin.