Molecular mechanism of Shengyang Yiwei Decoction in treating chronic kidney disease based on network pharmacology

Abstract

There is a serious worldwide health problem caused by chronic kidney disease (CKD), yet there are few viable therapies. Therapeutic promise in the treatment of chronic kidney disease (CKD) has been shown by the use of the traditional Chinese herbal compound Shengyang Yiwei Decoction (SYD). However, the chemical processes through which SYD exerts its effects are still unknown. The purpose of this network pharmacology research is to better understand the molecular mechanism of action of Shengyang Yiwei Decoction (SYD) in the treatment of chronic kidney disease (CKD). Traditional Chinese Medicine Systems Pharmacology (TCMSP) was first searched for information on the chemical components of Shengyang Yiwei Decoction. The molecular targets of SYD were then predicted using the Pharm Mapper service. After that, we used databases like DIG-SEE, TTD, and OMIM to zero down on the targets most closely linked to CKD. Cytoscape 3.2.1 was used to generate the component-target network representing SYD's therapy of CKD. In addition, KEGG signal pathways and GO biological processes were analyzed using the DAVID database, and the findings were displayed via OmicShare Tools. Twenty-two active components were isolated from Shengyang Yiwei Decoction, and they were linked to 36 therapeutic targets for CKD in the current investigation. According to the results of the network pharmacology study, 41 signaling pathways are involved in mediating the therapeutic effects of SYD. In addition, SYD's broad therapeutic impact in CKD therapy was shown to include 29 molecular activities, 14 cell components, and 91 biological processes. This research utilizes a multivariate analysis to provide light on the strategies and outcomes of treating CKD using Shengyang Yiwei Decoction. Clinical therapeutic methods for CKD management may benefit greatly from a thorough knowledge of the underlying processes and material foundation of this disease.

Keywords: Protein-protein interaction network; Shengyang Yiwei Decoction; chronic kidney disease; miRNA-mRNA regulatory network.

Figure 1

A. Protein interaction network diagram of common target of Shengyang Yiwei Decoction and CKD. B. Gene network diagram of target components of Shengyang Yiwei Decoction.

Figure 2

A. Network diagram of astragalus target genes. B. Ginseng target gene network. C. Gene network of coptis chinensis target. D. Pinellia ternata target gene network.

Figure 3

A. Bubble diagram of go cell composition pathway enrichment analysis. B. Bubble diagram of go molecular functional pathway enrichment analysis. C. Bubble diagram of KEGG signal pathway enrichment analysis.