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Review
. 2023 Dec 15;10(1):e23615.
doi: 10.1016/j.heliyon.2023.e23615. eCollection 2024 Jan 15.

The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Tae-Bin Yim  1 , Gyu-Ri Jeon  1 , Hye-Jin Lee  2 , Kyeong-Hwa Lee  2 , Hye-Min Heo  2 , Han-Gyul Lee  3 , Seungwon Kwon  4   3 , Seung-Yeon Cho  1   4 , Seong-Uk Park  1   4 , Woo-Sang Jung  4   3 , Sang-Kwan Moon  4   3 , Chang-Nam Ko  1   4 , Jung-Mi Park  1   4
Affiliations
Review

The effectiveness of Kami Guibi-tang for cognitive impairment patients: A retrospective chart review

Tae-Bin Yim et al. Heliyon. .

Abstract

Background: and Purpose: The number of patients with cognitive impairment is increasing worldwide. Therapeutic drugs that slow disease progression are being developed; however, further research is required. This study investigated the effects of Kami Guibi-tang on patients with various types of cognitive decline.

Methods: This study was a single-center, retrospective chart review of patients who visited KyungHee University Hospital at Gangdong from January 2015 to March 2022. The study included participants who took Kami Guibi-tang for more than 90 days and were assessed on the Korean version Mini-Mental State Examination (MMSE-K) scores before and after treatment. Participants who received other liquid herbal medicines during the treatment were excluded. The outcome of interest was changed scores in MMSE-K and Short form of Geriatric Depression Scale (S-GDS).

Results: A total of 31 participants were included. The total MMSE-K score significantly increased with time and showed a significant increase at 3 and 9 months compared with baseline. Among the MMSE-K subscores, the orientation subscore showed a significant increase at three months compared with baseline, and the attention and calculation subscore showed a significant increase with time. In addition, four participants with vascular dementia showed a significant increase in the total MMSE-K score over time and a significant increase after 9 months compared with baseline. The S-GDS score in 31 participants showed a significant decrease with time and at all time points compared with baseline.

Conclusions: Kami Guibi-tang may improve cognitive function in patients with cognitive decline.

Keywords: Alzheimer's disease; Herbal medicine; Kami Guibi-tang; Mild cognitive impairment; Subjective cognitive decline; Vascular dementia.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
A flow chart of our study.
See this image and copyright information in PMC

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