Evaluation of a new antihelminthic for trichuriasis, hookworm, and stronglyloidiasis

Abstract

Mebendazole was tested in a double-blind trial for its efficacy in the treatment and control of enteric helminths. One hundred and twenty-two children from a community near the Gulf of Carpentaria, and from a community in Cape York Peninsula in northern Queensland were divided into two equal groups to receive a course of either mebendazole or placebo after the identification of one or more intestinal helminths in a single pretreatment specimen of faeces. Between the tenth and twentieth days after a four-day course of treatment, three specimens of faeces were collected from each child. Mebendazole cured trichuriasis in 75% of cases, and over-all egg reduction rate was 96%. The drug also cured hookworm in 13 out of 15 cases and Strongyloides sterocoralis infestation in 14 out of 21 cases. Mebendazole was ineffective against Hymenolepis nana. No cases of Ascaris lumbricoides infestation were present. No side effects or adverse reactions to the drug were noted and patient acceptance was excellent. Mebendazole appears to be a safe drug for use in the treatment of human parasitic intestinal nematode infestations, and should be especially useful in the treatment and control of trichuriasis.

PIP: Mebendazole was tested in a double-blind trial for its efficacy in the treatment and control of enteric helminths. 122 children from a community near the Gulf of Carpentaria, and from a community in Cape York Peninsula in northern Queensland were divided into 2 equal groups to receive a course of either mebendazole or placebo after the identification of 1 or more intestinal helminths in a single pretreatment specimen of feces. Between days 10-20 following a 4-day course of treatment, 3 specimens of feces were collected from each child. Mebendazole cured trichuriasis in 75% of the cases, and the overall egg reduction rate was 96%. The drug also cured hookworm in 13 of 15 cases and Strongyloides sterocoralis infestation in 14 of 21 cases. Mebendazole was ineffective against Hymenolepsis nana. No cases of Ascaris lumbricoides infestation were present. No side effects or adverse reactions to the drug were noted and patient acceptance was excellent. Mebendazole appears to be a safe drug for use in the treatment of human parasitic intestinal nematode infestations and should be especially useful in the treatment and control of trichuriasis.