Graves' disease with pancytopenia: A rare case report

Abstract

Key clinical message: In this case report we describe a patient with Grave's disease (GD) who was first diagnosed with pancytopenia and did not have any typical symptoms of GD. His hematologic abnormalities were alleviated after treatment with an anti-thyroid drug. Hence, in patients with pancytopenia, GD should also be considered.

Abstract: A variety of hematologic abnormalities can be seen in Graves' disease (GD), however; here, we describe a patient with GD and a very rare complication; pancytopenia. His hematologic abnormalities and clinical status were alleviated after treatment with an anti-thyroid drug. Hence, in patients with pancytopenia and normal bone marrow examination, GD should also be considered.

Keywords: Graves' disease; case report; pancytopenia; thyrotoxicosis.

FIGURE 1

Peripheral blood smear shows mild anisocytosis with large platelet. Large platelet is shown with an arrow. (Wright‐Giemsa stain, Magnification: 100×).

FIGURE 2

(A) Bone marrow aspiration smear shows normocellular marrow and normal hematopoiesis (Wright‐Giemsa stain). (B) Bone marrow biopsy shows about 50%cellularity (H&E stain).