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. 2024;97(2):791-804.
doi: 10.3233/JAD-230794.

Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg

Valerie E Schröder  1   2 , Amna Skrozic  1   2 , Dorothee Erz  1   2 , Anne Kaysen  1 , Joëlle V Fritz  3 , Joao M Loureiro  2 , Deborah McIntyre  3 , Laure Pauly  1   2   3   4 , Jennifer Kemp  5 , Sabine K Schmitz  1 , Sophie Wagner  1 , Margarita Reyes  1 , Ruxandra Soare  1 , Venkata Satagopam  1 , Carlos Vega  1 , Piotr Gawron  1 , Kirsten Roomp  1 , Patricia Martins Conde  1 , Jochen Klucken  1   6   7 , Sebastian Köhler  8   9 , Tobias Hartmann  10   11 , Richard Dodel  12 , Anja K Leist  13 , Elke Kalbe  14 , Rejko Krüger  1   2   3
Affiliations

Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg

Valerie E Schröder et al. J Alzheimers Dis. 2024.

Abstract

Background: With continuously aging societies, an increase in the number of people with cognitive decline is to be expected. Aside from the development of causative treatments, the successful implementation of prevention strategies is of utmost importance to reduce the high societal burden caused by neurodegenerative diseases leading to dementia among which the most common cause is Alzheimer's disease.

Objective: The aim of the Luxembourgish "programme dementia prevention (pdp)" is to prevent or at least delay dementia in an at-risk population through personalized multi-domain lifestyle interventions. The current work aims to provide a detailed overview of the methodology and presents initial results regarding the cohort characteristics and the implementation process.

Methods: In the frame of the pdp, an extensive neuropsychological evaluation and risk factor assessment are conducted for each participant. Based on the results, individualized multi-domain lifestyle interventions are suggested.

Results: A total number of 450 participants (Mean age = 69.5 years; SD = 10.8) have been screened at different recruitment sites throughout the country, among whom 425 participants (94.4%) met the selection criteria.

Conclusions: We provide evidence supporting the feasibility of implementing a nationwide dementia prevention program and achieving successful recruitment of the target population by establishing a network of different healthcare providers.

Keywords: Alzheimer’s disease; cognition; dementia prevention; healthy aging; mild cognitive impairment; multi-domain lifestyle interventions; neuropsychological assessment; personalized prevention; risk factor assessment; subjective cognitive decline.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Fig. 1
Fig. 1
Recruitment pathway of participants in the frame of the pdp.
Fig. 2
Fig. 2
Geographical locations of pdp-recruitment hubs and voucher activities in Luxembourg. A) Map presenting locations of pdp-recruitment hubs and voucher activities. B) Map legend. C) Enlargement of activities/hubs within Luxembourg City. D) Population density map of Luxembourg. From Map of cantons of Luxembourg [political map], by Sémhur [wikigraphist], 2009, Wikimedia Commons [58]; Brinkhoff, T. (2022). City Population. (http://www.citypopulation.de). CC BY 3.0. [59]; Icons by Icons8 (https://icons8.com/) [60].
Fig. 3
Fig. 3
Demographic data for pdp-participants (n = 450) (i) and Cognitive status at baseline (ii). n, sample size; y, number of years; M, male; F, female; Ma, married; W, widowed; D, divorced; S, single; RP, registered partnership; L, Luxembourgish; F, French; P, Portuguese; I, Italian; G, German; Sp, Spanish; E, English; O, Other.
Fig. 4
Fig. 4
Specialization of referring physicians (i) and cumulative data of initial appointments over time (ii).
See this image and copyright information in PMC

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