The 5th edition of the World Health Organization Classification of mature lymphoid and stromal tumors - an overview and update

Ayoma D Attygalle¹, John K C Chan², Sarah E Coupland^{3

4}, Ming-Qing Du⁵, Judith A Ferry⁶, Daphne de Jong⁷, Dita Gratzinger⁸, Megan S Lim⁹, Kikkeri N Naresh¹⁰, Alina Nicolae¹¹, German Ott¹², Andreas Rosenwald¹³, Anna Schuh¹⁴, Reiner Siebert¹⁵

Affiliations

¹ Department of Histopathology, The Royal Marsden Hospital, London, UK.
² Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong, SAR China.
³ Department of Molecular and Clinical Cancer Medicine, ISMIB, University of Liverpool, Liverpool, UK.
⁴ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
⁵ Department of Pathology, University of Cambridge, Cambridge, UK.
⁶ Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁷ The Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁸ Department of Pathology, Stanford University School of Medicine, Stanford, USA.
⁹ Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
¹⁰ Fred Hutchinson Cancer Center, University of Washington, Seattle, USA.
¹¹ Department of Pathology, University Hospital of Strasbourg, Strasbourg, France.
¹² Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
¹³ Institute of Pathology, Julius-Maximilians-UniversitätWürzburg, and Cancer Center Mainfranken, Würzburg, Germany.
¹⁴ Department of Oncology, University of Oxford, Oxford, UK.
¹⁵ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

PMID: 38189838
DOI: 10.1080/10428194.2023.2297939

Review

The 5th edition of the World Health Organization Classification of mature lymphoid and stromal tumors - an overview and update

Ayoma D Attygalle et al. Leuk Lymphoma. 2024 Apr.

. 2024 Apr;65(4):413-429.

doi: 10.1080/10428194.2023.2297939. Epub 2024 Jan 8.

Authors

Affiliations

¹ Department of Histopathology, The Royal Marsden Hospital, London, UK.
² Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong, SAR China.
³ Department of Molecular and Clinical Cancer Medicine, ISMIB, University of Liverpool, Liverpool, UK.
⁴ Liverpool Clinical Laboratories, Liverpool University Hospitals Foundation Trust, Liverpool, UK.
⁵ Department of Pathology, University of Cambridge, Cambridge, UK.
⁶ Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁷ The Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁸ Department of Pathology, Stanford University School of Medicine, Stanford, USA.
⁹ Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
¹⁰ Fred Hutchinson Cancer Center, University of Washington, Seattle, USA.
¹¹ Department of Pathology, University Hospital of Strasbourg, Strasbourg, France.
¹² Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
¹³ Institute of Pathology, Julius-Maximilians-UniversitätWürzburg, and Cancer Center Mainfranken, Würzburg, Germany.
¹⁴ Department of Oncology, University of Oxford, Oxford, UK.
¹⁵ Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

PMID: 38189838
DOI: 10.1080/10428194.2023.2297939

Abstract

The purpose of this review is to give an overview on the conceptual framework and major developments of the upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid tumours (WHO-HAEM5) and to highlight the most significant changes made in WHO-HAEM5 compared with the revised 4^th edition (WHO-HAEM4R) of lymphoid and stromal neoplasms. The changes from the revised 4th edition include the reorganization of entities by means of a hierarchical system that is realized throughout the 5th edition of the WHO classification of tumors of all organ systems, a modification of nomenclature for some entities, the refinement of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities. For the first time, tumor-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms are included in the classification.

Keywords: WHO-HAEM5; modification of nomenclature; refinement of diagnostic criteria.

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The 5th edition of the World Health Organization Classification of mature lymphoid and stromal tumors - an overview and update

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The 5th edition of the World Health Organization Classification of mature lymphoid and stromal tumors - an overview and update

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