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. 2024 Jan 9;110(2):250-253.
doi: 10.4269/ajtmh.23-0552. Print 2024 Feb 7.

Female Genital Schistosomiasis Lesion Resolution Post-Treatment with Praziquantel in Zambian Adults

Chishiba Kabengele  1 , Sepo Mwangelwa  2 , William Kilembe  1 , Bellington Vwalika  1 , Mubiana Inambao  2 , Vernon Moonga  1 , Constance Himukumbwa  2 , W Evan Secor  3 , Rachel Parker  4 , Amanda Tichacek  4 , Amaya L Bustinduy  5 , Susan Allen  4 , Kristin M Wall  4
Affiliations

Female Genital Schistosomiasis Lesion Resolution Post-Treatment with Praziquantel in Zambian Adults

Chishiba Kabengele et al. Am J Trop Med Hyg. .

Abstract

We evaluated changes in female genital schistosomiasis (FGS) 6 to 12 months after praziquantel treatment among 43 adult Zambian women. Most women (60%) experienced decreased FGS severity and 23% experienced complete lesion resolution. This is the first study to demonstrate a meaningful effect of praziquantel treatment of FGS in adult women.

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Conflict of interest statement

Disclosure: This study was approved by the Institutional Review Board of Emory University (IRB00071160) and the Research Ethics Committee of the University of Zambia (011-10-14). Participants completed written informed consent. This activity was reviewed by the CDC and was conducted consistent with applicable federal law and CDC policy. The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the CDC.

Figures

Figure 1.
Figure 1.
Representative images taken during colposcopy before and after praziquantel treatment of women experiencing (A) female genital schistosomiasis lesion resolution or (B) decreased lesion severity.
See this image and copyright information in PMC

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