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Review
. 2025;13(1):117-132.
doi: 10.2174/0122117385280541231130055458.

Overcoming Solubility Challenges: Self-emulsifying Systems for Enhancing the Delivery of Poorly Water-Soluble Antiviral Drugs

Devesh U Kapoor  1 , Deepak Sharma  2 , Mansi Gaur  3 , Bhupendra G Prajapati  4 , Sontaya Limmatvapirat  5 , Pornsak Sriamornsak  5   6   7
Affiliations
Review

Overcoming Solubility Challenges: Self-emulsifying Systems for Enhancing the Delivery of Poorly Water-Soluble Antiviral Drugs

Devesh U Kapoor et al. Pharm Nanotechnol. 2025.

Abstract

The primary goal of drug formulation is to improve a drug's bioavailability in the body. However, poorly water-soluble drugs present challenging issues related to their solubility and bioavailability factors. Emerging technologies, such as lipid-based drug delivery systems, including micro- or nanoemulsifying drug delivery systems, have become increasingly relevant to address the above challenges. This review presents a thorough overview of self-emulsifying drug delivery systems (SEDDS). It covers the properties, principles, self-emulsification mechanism, formulation strategies, and characterization methods of SEDDS. This review also addresses the delivery of antiviral agents through SEDDS. Moreover, it summarizes the marketed formulations of SEDDS consisting of antiviral agents. This review offers a comprehensive and valuable resource for future perspectives on SEDDS and their potential applications in antiviral drug delivery.

Keywords: Self-emulsifying drug delivery systems; antiviral drug.; biopharmaceutical classification system; cosurfactant; pharmacokinetics; quality target product profile.

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