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Review
. 2024 Feb 7;68(2):e0133923.
doi: 10.1128/aac.01339-23. Epub 2024 Jan 9.

Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance

Johann D D Pitout  1   2   3 , Gisele Peirano  1   2 , Yasufumi Matsumura  4 , Rebekah DeVinney  1 , Liang Chen  5   6
Affiliations
Review

Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance

Johann D D Pitout et al. Antimicrob Agents Chemother. .

Abstract

Escherichia coli sequence type ST410 is an emerging carbapenemase-producing multidrug-resistant (MDR) high-risk One-Health clone with the potential to significantly increase carbapenem resistance among E. coli. ST410 belongs to two clades (ST410-A and ST410-B) and three subclades (ST410-B1, ST410-B2, and ST410-B3). After a fimH switch between clades ST410-A and ST410-B1, ST410-B2 and ST410-B3 subclades showed a stepwise progression toward developing MDR. (i) ST410-B2 initially acquired fluoroquinolone resistance (via homologous recombination) in the 1980s. (ii) ST410-B2 then obtained CMY-2, CTX-M-15, and OXA-181 genes on different plasmid platforms during the 1990s. (iii) This was followed by the chromosomal integration of blaCMY-2, fstl YRIN insertion, and ompC/ompF mutations during the 2000s to create the ST410-B3 subclade. (iv) An IncF plasmid "replacement" scenario happened when ST410-B2 transformed into ST410-B3: F36:31:A4:B1 plasmids were replaced by F1:A1:B49 plasmids (both containing blaCTX-M-15) followed by blaNDM-5 incorporation during the 2010s. User-friendly cost-effective methods for the rapid identification of ST410 isolates and clades are needed because limited data are available about the frequencies and global distribution of ST410 clades. Basic mechanistic, evolutionary, surveillance, and clinical studies are urgently required to investigate the success of ST410 (including the ability to acquire successive MDR determinants). Such information will aid with management and prevention strategies to curb the spread of carbapenem-resistant E. coli. The medical community can ill afford to ignore the spread of a global E. coli clone with the potential to end the carbapenem era.

Keywords: Escherichia coli; ST410; carbapenemases; high-risk clones.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig 1
The global distribution of fluoroquinolone-resistant, extended-spectrum β-lactamase, and carbapenemase-producing E. coli ST410.
Fig 2
Fig 2
The stepwise acquisition over time of antimicrobial resistance determinants in the evolution of ST410 subclades.
Fig 3
Fig 3
The stepwise acquisition over time of antimicrobial resistance determinants in the evolution of ST131 subclades.
See this image and copyright information in PMC

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