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Case Reports
. 1979 Sep 13;281(5727):122-5.
doi: 10.1038/281122a0.

A structurally abnormal insulin causing human diabetes

H Tager, B Given, D Baldwin, M Mako, J Markese, A Rubenstein, J Olefsky, M Kobayashi, O Kolterman, R Poucher
Case Reports

A structurally abnormal insulin causing human diabetes

H Tager et al. Nature. .

Abstract

Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.

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