Case Reports
doi: 10.1038/281122a0.
A structurally abnormal insulin causing human diabetes
- PMID: 381941
- DOI: 10.1038/281122a0
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Case Reports
A structurally abnormal insulin causing human diabetes
Nature.
.
Abstract
Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.
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