Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;42(11):1661-1666.
doi: 10.1038/s41587-023-02072-4. Epub 2024 Jan 9.

Delivery of a sebum modulator by an engineered skin microbe in mice

Nastassia Knödlseder  1 , María-José Fábrega #  1 , Javier Santos-Moreno #  1 , Joan Manils  2   3 , Lorena Toloza  1 , Maria Marín Vilar  1   4 , Cristina Fernández  1 , Katrina Broadbent  5 , Julien Maruotti  6 , Hélène Lemenager  6 , Carlo Carolis  5 , Christos C Zouboulis  7 , Concepció Soler  2   8 , Rolf Lood  9 , Holger Brüggemann  10 , Marc Güell  11   12
Affiliations

Delivery of a sebum modulator by an engineered skin microbe in mice

Nastassia Knödlseder et al. Nat Biotechnol. 2024 Nov.

Abstract

Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.

PubMed Disclaimer

Conflict of interest statement

Competing interests M.G., N.K., M.J.F. and J.S.M. are inventors of a European patent application submitted by University Pompeu Fabra.

References

    1. Leventhal, D. S. et al. Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nat. Commun. 11, 2739 (2020). - PubMed - PMC - DOI
    1. Isabella, V. M. et al. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria. Nat. Biotechnol. 36, 857–864 (2018). - PubMed - DOI
    1. Mao, N., Cubillos-Ruiz, A., Cameron, D. E. & Collins, J. J. Probiotic strains detect and suppress cholera in mice. Sci. Transl. Med. 10, eaao2586 (2018). - PubMed - PMC - DOI
    1. Danino, T. et al. Programmable probiotics for detection of cancer in urine. Sci. Transl. Med. 7, 289ra84 (2015). - PubMed - PMC - DOI
    1. Hwang, I. Y. et al. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models. Nat. Commun. 8, 15028 (2017). - PubMed - PMC - DOI

LinkOut - more resources