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. 2024 Jan-Feb;40(1Part-I):140-144.
doi: 10.12669/pjms.40.1.8025.

Recurrence of portosystemic encephalopathy in cirrhotic patients and its risk factors

Masood Muhammad Karim  1 , Abdullah Bin Khalid  2 , Zahabia Sohail  3 , Mohammad Yasrab  4
Affiliations

Recurrence of portosystemic encephalopathy in cirrhotic patients and its risk factors

Masood Muhammad Karim et al. Pak J Med Sci. 2024 Jan-Feb.

Abstract

Objectives: Recurrent episodes of Portal Systemic Encephalopathy (PSE), poses a significant burden of illness on the patients and healthcare system. The objective of this study was to assess the recurrence of PSE in cirrhotic patients after index episode of PSE and to identify various risk factors associated with it.

Methods: A retrospective, single-centre study was conducted at Aga Khan University Hospital over a span of one year. Patients who were admitted first time with PSE and admitted within three months of index PSE were enrolled in the study. Variables assessed were demographic data, associated comorbid conditions, aetiology of cirrhosis, Child-Turcotte-Pugh (CTP) score, Model of End-Stage Liver Disease (MELD) score, PSE grade, laboratory tests, ascites with spontaneous bacterial peritonitis (SBP), variceal bleeding. Statistical analysis was done and variables of those who developed recurrence were compared with those who did not.

Results: Fifty one patients were recruited. Thirty three (64.7%) were readmitted with PSE. On comparative analysis of both groups; infection, Meld score, low albumin, and raised total bilirubin showed significant P-value (<0.05).

Conclusion: Identification of risk factors during assessment can reduce the recurrence of PSE. We would recommend to validate result of our study on a large scale prospectively.

Keywords: Portosystemic Encephalopathy; Recurrence; Risk Factors.

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Conflict of interest statement

Conflicts of interest and source of funding statement: All the aforementioned authors of this manuscript, in compliance with the ICMJE uniform disclosure form, declare that no financial support was received from any organisation and that they have no financial relationships with any organisations that might have an interest in the findings of this study.

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