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Review
. 2024 Feb;22(1):105-114.
doi: 10.1007/s11914-023-00857-9. Epub 2024 Jan 10.

The Role of Osteocytes in Pre-metastatic Niche Formation

Emma N Briggs  1 , Maureen E Lynch  2   3
Affiliations
Review

The Role of Osteocytes in Pre-metastatic Niche Formation

Emma N Briggs et al. Curr Osteoporos Rep. 2024 Feb.

Abstract

Purpose of review: The formation of a pre-metastatic niche (PMN), in which primary cancer cells prime the distant site to be favorable to their engraftment and survival, may help explain the strong osteotropism observed in multiple cancers, such as breast and prostate. PMN formation, which includes extracellular matrix remodeling, increased angiogenesis and vascular permeability, enhanced bone marrow-derived cell recruitment and immune suppression, has mostly been described in soft tissues. In this review, we summarize current literature of PMN formation in bone. We also present evidence of a potential role for osteocytes to be the primary mediators of PMN development.

Recent findings: Osteocytes regulate the bone microenvironment in myriad ways beyond canonical bone tissue remodeling, including changes that contribute to PMN formation. Perilacunar tissue remodeling, which has been observed in both bone and non-bone metastatic cancers, is a potential mechanism by which osteocyte-cancer cell signaling stimulates changes to the bone microenvironment. Osteocytes also protect against endothelial permeability, including that induced by cancer cells, in a loading-mediated process. Finally, osteocytes are potent regulators of cells within the bone marrow, including progenitors and immune cells, and might be involved in this aspect of PMN formation. Osteocytes should be examined for their role in PMN formation.

Keywords: Bone metastasis; Mechanical loading; Microenvironment; Osteocyte; Pre-metastatic niche.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Jiang W, Rixiati Y, Zhao B, Li Y, Tang C, Liu J. Incidence, prevalence, and outcomes of systemic malignancy with bone metastases. https://doi.org/10.1177/2309499020915989 .
    1. Costa-Silva B, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2014;17(6):816–26. https://doi.org/10.1038/ncb3169 . - DOI
    1. Zeng Z, et al. Cancer-derived exosomal miR-25–3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat Commun. 2018;9(1). https://doi.org/10.1038/S41467-018-07810-W .
    1. Paolillo M, Schinelli S. Extracellular matrix alterations in metastatic processes. Int J Mol Sci. 2019;20(19). https://doi.org/10.3390/IJMS20194947 .
    1. So A, Chin J, Fleshner N, Saad F. Management of skeletal-related events in patients with advanced prostate cancer and bone metastases: incorporating new agents into clinical practice. Can Urol Assoc J. 2012;6(6):465. https://doi.org/10.5489/CUAJ.12149 . - DOI - PMC

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