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Comment
. 2024 Jan 9;57(1):8-10.
doi: 10.1016/j.immuni.2023.12.015.

TIMely connections: APOE4, aging, and Alzheimer's

Qingyun Li  1
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TIMely connections: APOE4, aging, and Alzheimer's

Qingyun Li. Immunity. .
Free article

Abstract

How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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