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Case Reports
. 2024 Jan 9;17(1):e256417.
doi: 10.1136/bcr-2023-256417.

Intravenous lipid emulsion for a life-threatening prothipendyl intoxication

Anne Meunier  1 , Pierre Goffin  2 , Marine Deville  3 , Pierre Demaret  1
Affiliations
Case Reports

Intravenous lipid emulsion for a life-threatening prothipendyl intoxication

Anne Meunier et al. BMJ Case Rep. .

Abstract

Prothipendyl, a lipophilic neuroleptic drug, requires a careful dosage regimen due to its potential side effects, including life-threatening arrhythmias.This report outlines a case of severe prothipendyl intoxication, its management and the successful utilisation of Intralipid, an intravenous lipid emulsion, in treating ventricular arrhythmia postmassive prothipendyl ingestion. Additionally, the mechanism of action of Intralipid and the rebound concentration of the lipophilic drug in such scenarios are discussed.

Keywords: Adult intensive care; Cardiovascular system; Drug interactions; Drugs and medicines; Toxicology.

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Conflict of interest statement

Competing interests: None declared.

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