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. 2023 Dec 26;14(1):55.
doi: 10.3390/diagnostics14010055.

Increased Risk of Benign Prostate Hyperplasia (BPH) in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

Woo Jin Bang  1 , Hyo Geun Choi  2 , Ho Suk Kang  3 , Mi Jung Kwon  4 , Ji Hee Kim  5 , Joo-Hee Kim  6 , So Young Kim  7
Affiliations

Increased Risk of Benign Prostate Hyperplasia (BPH) in Patients with Gout: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

Woo Jin Bang et al. Diagnostics (Basel). .

Abstract

A previous study reported a high risk of benign prostatic hyperplasia (BPH) in patients with gout. This study intended to evaluate the risk of BPH in gout patients. A total of 514,866 Korean National Health Insurance Service-Health Screening Cohorts were retrieved from 2002 to 2019. Among these individuals, 14,961 gout patients and 58,764 control participants were matched based on demographic factors. The incidence of BPH during the follow-up periods was collected for both the gout and control groups. The risk of BPH was analyzed using stratified Cox proportional hazard models, and hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Secondary analyses were conducted based on demographic factors and comorbidities. The incidence of BPH was 23.40% in gout patients and 20.70% in control participants. In the adjusted model, the HR of BPH was 1.13-fold higher in gout patients than in the control group (95% CI = 1.09-1.18). Compared with the ≥60-year-old group, the <60-year-old group demonstrated a higher HR for BPH in gout patients (1.19 [1.13-1.24] vs. 1.07 [1.01-1.13]). The risk of BPH in gout patients was consistent according to various comorbidities. Patients with gout demonstrated a greater risk of BPH than participants without gout. The young adult population had a higher risk of BPH related to gout.

Keywords: benign prostate hyperplasia; cohort studies; epidemiology; gout; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A schematic illustration of the participant selection process used in the present study. Among a total of 514,866 participants, 14,691 gout participants were matched with 58,764 control participants for age, sex, income, and region of residence.
Figure 2
Figure 2
The risk of benign prostate hyperplasia in patients with gout compared with the control group.
See this image and copyright information in PMC

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