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Review
. 2023 Dec 23;16(1):87.
doi: 10.3390/cancers16010087.

Novel HER-2 Targeted Therapies in Breast Cancer

Catarina Lopes Fernandes  1 , Diogo J Silva  1 , Alexandra Mesquita  1   2
Affiliations
Review

Novel HER-2 Targeted Therapies in Breast Cancer

Catarina Lopes Fernandes et al. Cancers (Basel). .

Abstract

Human epidermal growth factor 2 (HER-2)-positive breast cancer represents 15-20% of all breast cancer subtypes and has an aggressive biological behavior with worse prognosis. The development of HER-2-targeted therapies has changed the disease's course, having a direct impact on survival rates and quality of life. Drug development of HER-2-targeting therapies is a prolific field, with numerous new therapeutic strategies showing survival benefits and gaining regulatory approval in recent years. Furthermore, the acknowledgement of the survival impact of HER-2-directed therapies on HER-2-low breast cancer has contributed even more to advances in the field. The present review aims to summarize the newly approved therapeutic strategies for HER-2-positive breast cancer and review the new and exploratory HER-2-targeted therapies currently under development.

Keywords: HER-2; breast cancer; novel therapies.

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Conflict of interest statement

The authors declare no conflict of interest.

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