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. 2023 Dec 19;13(1):7.
doi: 10.3390/jcm13010007.

Dynamic Evaluation of Vitamin D Metabolism in Post-Bariatric Patients

Alexandra Povaliaeva  1 , Artem Zhukov  1 , Alina Tomilova  1 , Axenia Bondarenko  1 , Maksim Ovcharov  1 , Mariya Antsupova  1 , Vitaliy Ioutsi  1 , Ekaterina Shestakova  1 , Marina Shestakova  1 , Ekaterina Pigarova  1 , Liudmila Rozhinskaya  1 , Natalia Mokrysheva  1
Affiliations

Dynamic Evaluation of Vitamin D Metabolism in Post-Bariatric Patients

Alexandra Povaliaeva et al. J Clin Med. .

Abstract

Background: findings from the previously conducted studies indicate altered regulatory mechanisms of calcium and vitamin D metabolism in obese patients and a role for bariatric surgery in regulating vitamin D metabolism; however, the available data is controversial and does not provide an adequate understanding of the subject.

Methods: we evaluated serum parameters of vitamin D and mineral metabolism (vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3, and 24,25(OH)2D3), vitamin D-binding protein (DBP), free 25(OH)D, fibroblast growth factor 23 (FGF-23), parathyroid hormone (PTH), total calcium, albumin, phosphorus, creatinine, magnesium) in 30 patients referred for bariatric surgery in comparison with 30 healthy volunteers of similar age, sex and baseline 25(OH)D3. Patients were also followed up with repeated laboratory assessments 3 months and 6 months after surgery. During the first 3 months, patients were prescribed high-dose cholecalciferol therapy (50,000 IU per week), with subsequent correction based on the results of the 3-month visit examination.

Results: Preoperatively, patients with morbid obesity were characterized by a high prevalence of vitamin D deficiency (median 25(OH)D3 level 11.9 (6.8; 22.2) ng/mL), significantly lower levels of active vitamin D metabolite 1,25(OH)2D3 (20 (10; 37) vs. 39 (33; 50) pg/mL, p < 0.001), lower serum albumin-adjusted calcium levels (2.24 (2.20; 2.32) vs. 2.31 (2.25; 2.35) mmol/L, p = 0.009) and magnesium levels (0.79 (0.72; 0.82) vs. 0.82 (0.78; 0.85) mmol/L, p = 0.043) with simultaneous similar PTH levels (p = 0.912), and higher DBP levels (328 (288; 401) vs. 248 (217; 284) mg/L, p < 0.001). The 25(OH)D3 levels remained suboptimal (24.5 (14.7; 29.5) ng/mL at the 3-month visit and 17.9 (12.4; 21.0) ng/mL at the 6-month visit, p = 0.052) despite recommended high-dose cholecalciferol supplementation. Patients also demonstrated an increase in 1,25(OH)2D3 levels (38 (31; 52) pg/mL at the 3-month visit and 49 (29; 59) pg/mL at the 6-month visit, p < 0.001) without a change in PTH or calcium levels during the follow-up.

Conclusion: our results of a comprehensive laboratory evaluation of vitamin D status and mineral metabolism in patients undergoing bariatric surgery highlight the importance of improving current clinical guidelines, as well as careful monitoring and education of patients.

Keywords: bariatric surgery; mass spectrometry; obesity; vitamin D; vitamin D deficiency.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., Murad M.H., Weaver C.M. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. Med. J. Clin. Endocrinol. Metab. 2011;96:1911–1930. doi: 10.1210/jc.2011-0385. - DOI - PubMed
    1. Wortsman J., Matsuoka L.Y., Chen T.C., Lu Z., Holick M.F. Decreased bioavailability of vitamin D in obesity. Am. J. Clin. Nutr. 2000;72:690–693. doi: 10.1093/ajcn/72.3.690. - DOI - PubMed
    1. Blum M., Dolnikowski G., Seyoum E., Harris S.S., Booth S.L., Peterson J., Saltzman E., Dawson-Hughes B. Vitamin D3 in fat tissue. Endocrine. 2008;33:90–94. doi: 10.1007/s12020-008-9051-4. - DOI - PMC - PubMed
    1. Drincic A.T., Armas L.A., van Diest E.E., Heaney R.P. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity. 2012;20:1444–1448. doi: 10.1038/oby.2011.404. - DOI - PubMed
    1. Carrelli A., Bucovsky M., Horst R., Cremers S., Zhang C., Bessler M., Schrope B., Evanko J., Blanco J., Silverberg S.J., et al. Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women. J. Bone Miner. Res. 2017;32:237–242. doi: 10.1002/jbmr.2979. - DOI - PMC - PubMed

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