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Review
. 2023 Dec 21;13(1):40.
doi: 10.3390/jcm13010040.

Colorectal Cancer: Current Updates and Future Perspectives

Rosa Marcellinaro  1 , Domenico Spoletini  1 , Michele Grieco  1 , Pasquale Avella  2   3 , Micaela Cappuccio  2 , Raffaele Troiano  1 , Giorgio Lisi  1 , Giovanni M Garbarino  1 , Massimo Carlini  1
Affiliations
Review

Colorectal Cancer: Current Updates and Future Perspectives

Rosa Marcellinaro et al. J Clin Med. .

Abstract

Colorectal cancer is a frequent neoplasm in western countries, mainly due to dietary and behavioral factors. Its incidence is growing in developing countries for the westernization of foods and lifestyles. An increased incidence rate is observed in patients under 45 years of age. In recent years, the mortality for CRC is decreased, but this trend is slowing. The mortality rate is reducing in those countries where prevention and treatments have been implemented. The survival is increased to over 65%. This trend reflects earlier detection of CRC through routine clinical examinations and screening, more accurate staging through advances in imaging, improvements in surgical techniques, and advances in chemotherapy and radiation. The most important predictor of survival is the stage at diagnosis. The screening programs are able to reduce incidence and mortality rates of CRC. The aim of this paper is to provide a comprehensive overview of incidence, mortality, and survival rate for CRC.

Keywords: colorectal cancer; incidence; mortality; screening; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Brenner H., Kloor M., Pox C.P. Colorectal cancer. Lancet. 2014;383:1490–1502. doi: 10.1016/S0140-6736(13)61649-9. - DOI - PubMed
    1. Rocca A., Cipriani F., Belli G., Berti S., Boggi U., Bottino V., Cillo U., Cescon M., Cimino M., Corcione F., et al. The Italian Consensus on minimally invasive simultaneous resections for synchronous liver metastasis and primary colorectal cancer: A Delphi methodology. Updates Surg. 2021;73:1247–1265. doi: 10.1007/s13304-021-01100-9. - DOI - PubMed
    1. Avella P., Vaschetti R., Cappuccio M., Gambale F., De Meis L., Rafanelli F., Brunese M.C., Guerra G., Scacchi A., Rocca A. The role of liver surgery in simultaneous synchronous colorectal liver metastases and colorectal cancer resections: A literature review of 1730 patients underwent open and minimally invasive surgery. Minerva Surg. 2022;77:582–590. doi: 10.23736/S2724-5691.22.09716-7. - DOI - PubMed
    1. Carbone F., Chee Y., Rasheed S., Cunningham D., Bhogal R.H., Jiao L., Tekkis P., Kontovounisios C. Which surgical strategy for colorectal cancer with synchronous hepatic metastases provides the best outcome? A comparison between primary first, liver first and simultaneous approach. Updates Surg. 2022;74:451–465. doi: 10.1007/s13304-021-01234-w. - DOI - PubMed
    1. Baidoun F., Elshiwy K., Elkeraie Y., Merjaneh Z., Khoudari G., Sarmini M.T., Gad M., Al-Husseini M., Saad A. Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes. Curr. Drug Targets. 2021;22:998–1009. doi: 10.2174/1389450121999201117115717. - DOI - PubMed

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