Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 21;13(1):54.
doi: 10.3390/jcm13010054.

Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges

Perrine Devos  1 , Paul Guedeney  1 , Gilles Montalescot  1   2 ; ACTION Study Group
Affiliations
Review

Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges

Perrine Devos et al. J Clin Med. .

Abstract

Patent foramen ovale (PFO) concerns nearly a quarter of the general population and incidence may reach up to 50% in patients with cryptogenic stroke. Recent randomized clinical trials confirmed that percutaneous closure of PFO-related stroke reduces the risk of embolic event recurrence. PFO also comes into play in other pathogenic conditions, such as migraine, decompression sickness or platypnea-orthodeoxia syndrome, where the heterogeneity of patients is high and evidence for closure is less well-documented. In this review, we describe the current indications for PFO percutaneous closure and the remaining challenges, and try to provide future directions regarding the technique and its indications.

Keywords: PFO; PFO closure; cryptogenic stroke; decompression sickness; migraine; orthodeoxia syndrome; patent foramen ovale; residual shunt.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chiari network.
See this image and copyright information in PMC

References

    1. Koutroulou I., Tsivgoulis G., Tsalikakis D., Karacostas D., Grigoriadis N., Karapanayiotides T. Epidemiology of Patent Foramen Ovale in General Population and in Stroke Patients: A Narrative Review. Front. Neurol. 2020;11:281. doi: 10.3389/fneur.2020.00281. - DOI - PMC - PubMed
    1. Belvís R., Tizzano E.F., Martí-Fàbregas J., Leta R.G., Baena M., Carreras F., Pons-Lladó G., Baiget M., Martí-Vilalta J.L. Mutations in the NKX2-5 Gene in Patients with Stroke and Patent Foramen Ovale. Clin. Neurol. Neurosurg. 2009;111:574–578. doi: 10.1016/j.clineuro.2009.04.004. - DOI - PubMed
    1. Paolucci M., Vincenzi C., Romoli M., Amico G., Ceccherini I., Lattanzi S., Bersano A., Longoni M., Sacco S., Vernieri F., et al. The Genetic Landscape of Patent Foramen Ovale: A Systematic Review. Genes. 2021;12:1953. doi: 10.3390/genes12121953. - DOI - PMC - PubMed
    1. Lechat P.H., Mas J.L., Lascault G., Loron P.H., Theard M., Klimczac M., Drobinski G., Thomas D., Grosgogeat Y. Prevalence of Patent Foramen Ovale in Patients with Stroke. N. Engl. J. Med. 1988;318:1148–1152. doi: 10.1056/NEJM198805053181802. - DOI - PubMed
    1. Hara H., Virmani R., Ladich E., Mackey-Bojack S., Titus J., Reisman M., Gray W., Nakamura M., Mooney M., Poulose A., et al. Patent Foramen Ovale: Current Pathology, Pathophysiology, and Clinical Status. J. Am. Coll. Cardiol. 2005;46:1768–1776. doi: 10.1016/j.jacc.2005.08.038. - DOI - PubMed

LinkOut - more resources