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Review
. 2023 Dec 21;13(1):54.
doi: 10.3390/jcm13010054.

Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges

Perrine Devos  1 , Paul Guedeney  1 , Gilles Montalescot  1   2 ; ACTION Study Group
Affiliations
Review

Patent Foramen Ovale Percutaneous Closure: Evolution and Ongoing Challenges

Perrine Devos et al. J Clin Med. .

Abstract

Patent foramen ovale (PFO) concerns nearly a quarter of the general population and incidence may reach up to 50% in patients with cryptogenic stroke. Recent randomized clinical trials confirmed that percutaneous closure of PFO-related stroke reduces the risk of embolic event recurrence. PFO also comes into play in other pathogenic conditions, such as migraine, decompression sickness or platypnea-orthodeoxia syndrome, where the heterogeneity of patients is high and evidence for closure is less well-documented. In this review, we describe the current indications for PFO percutaneous closure and the remaining challenges, and try to provide future directions regarding the technique and its indications.

Keywords: PFO; PFO closure; cryptogenic stroke; decompression sickness; migraine; orthodeoxia syndrome; patent foramen ovale; residual shunt.

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Conflict of interest statement

The authors declare no conflict of interest.

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Figure 1
Chiari network.
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