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Review
. 2023 Dec 24;13(1):109.
doi: 10.3390/jcm13010109.

An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome

Mateusz Matwiejuk  1 , Hanna Myśliwiec  1 , Adrian Chabowski  2 , Iwona Flisiak  1
Affiliations
Review

An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome

Mateusz Matwiejuk et al. J Clin Med. .

Abstract

Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome.

Keywords: HGF; M-CSF; NGF b; PDGF-BB; SCF; bFGF; metabolic syndrome; psoriasis; skin; skin diseases.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The search process.
Figure 2
Figure 2
Examples of growth factors.
Figure 3
Figure 3
The potential mediating roles of chemokines between psoriasis and its comorbidities.
See this image and copyright information in PMC

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