Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 26;13(1):138.
doi: 10.3390/jcm13010138.

Gout and Migraines: Exploring the Complex Link in a 16-Year Longitudinal Study of the Korean Population

Ho Suk Kang  1 , Ji Hee Kim  2 , Joo-Hee Kim  3 , Woo Jin Bang  4 , Hyo Geun Choi  5 , Nan Young Kim  6 , Ha Young Park  7 , Kyung Chan Choi  8 , Younghee Choi  9   10 , Mi Jung Kwon  10   11
Affiliations

Gout and Migraines: Exploring the Complex Link in a 16-Year Longitudinal Study of the Korean Population

Ho Suk Kang et al. J Clin Med. .

Abstract

Despite the growing prevalence of gout and its associated health concerns as a chronic disorder, population-based studies on its link to migraines are scarce. We conducted a 16-year longitudinal study in a Korean population to investigate the relationship between gout and migraines, including different subtypes. We enrolled 23,137 patients with gout and matched them with 92,548 controls based on age, sex, income, and residence. Using Cox proportional hazards models, we calculated hazard ratios to assess the likelihood of migraines while considering relevant factors. During the follow-up, 1000 gout patients and 3214 controls experienced migraines. After adjusting for various factors, including demographics, health-related variables, and weight categories, the gout group had a 1.26-fold higher likelihood of developing migraines compared to the group without gout. This association was particularly strong for migraines without aura, while it was not significant for migraines with aura. In summary, our study reveals a significant link between gout and migraines in the Korean population, emphasizing the complex relationship among chronic disorders, with a specific focus on migraine subtypes.

Keywords: chronic disorder; gout; longitudinal follow-up study; migraine risk; national health screening cohort database.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Diagram outlining the participant selection process employed in this study. Out of the initial pool of 514,866 participants in the Korean National Health Insurance Service-Health Screening Cohort (KNHIS-HSC) database, a total of 23,137 patients with gout were carefully matched with 92,548 control participants based on age, sex, income, and region of residence.
Figure 2
Figure 2
Kaplan–Meier incidence probabilities for overall migraines (A) and the subtypes, including migraines with aura (B) and migraines without aura (C), were assessed in patients with gout and the control populations over 16 years from the index date.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Kuo C.F., Grainge M.J., Zhang W., Doherty M. Global epidemiology of gout: Prevalence, incidence and risk factors. Nat. Rev. Rheumatol. 2015;11:649–662. doi: 10.1038/nrrheum.2015.91. - DOI - PubMed
    1. Kuo C.F., Grainge M.J., Mallen C., Zhang W., Doherty M. Rising burden of gout in the UK but continuing suboptimal management: A nationwide population study. Ann. Rheum. Dis. 2015;74:661–667. doi: 10.1136/annrheumdis-2013-204463. - DOI - PMC - PubMed
    1. Zhu Y., Pandya B.J., Choi H.K. Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum. 2011;63:3136–3141. doi: 10.1002/art.30520. - DOI - PubMed
    1. Kuo C.F., Grainge M.J., See L.C., Yu K.H., Luo S.F., Zhang W., Doherty M. Epidemiology and management of gout in Taiwan: A nationwide population study. Arthritis Res. Ther. 2015;17:13. doi: 10.1186/s13075-015-0522-8. - DOI - PMC - PubMed
    1. Kim J.W., Kwak S.G., Lee H., Kim S.K., Choe J.Y., Park S.H. Prevalence and incidence of gout in Korea: Data from the national health claims database 2007–2015. Rheumatol. Int. 2017;37:1499–1506. doi: 10.1007/s00296-017-3768-4. - DOI - PubMed

LinkOut - more resources