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. 2023 Dec 27;13(1):144.
doi: 10.3390/jcm13010144.

Obstructive Sleep Apnea and Its Influence on Intracranial Aneurysm

Tae Young Jung  1 , Eunkyu Lee  2 , Minhae Park  2 , Jin-Young Lee  3 , Yun Soo Hong  4 , Juhee Cho  5   6   7 , Eliseo Guallar  4   5   6 , Sang Duk Hong  2 , Yong Gi Jung  2 , Seonhye Gu  8 , Jae Wook Ryoo  9 , Eun-Yeon Joo  10 , Je Young Yeon  11 , Gwanghui Ryu  2 , Hyo Yeol Kim  2
Affiliations

Obstructive Sleep Apnea and Its Influence on Intracranial Aneurysm

Tae Young Jung et al. J Clin Med. .

Abstract

Obstructive sleep apnea syndrome (OSAS) is associated with cerebrovascular disease, which can lead to life-threatening outcomes. The purpose of the study was to investigate the relationship between OSAS and comorbid intracranial aneurysms. We retrospectively reviewed 564 patients who underwent a polysomnography and brain magnetic resonance angiography as part of their health checkup. We calculated the prevalence of an intracranial aneurysm and OSAS in patients and measured the size of the intracranial aneurysm if present. The mean patient age was 55.6 ± 8.5 years, and 82.3% of them were men. The prevalence of an intracranial aneurysm in patients with OSAS was 12.1%, which is significantly higher than patients with non-OSAS (5.9%, p = 0.031). Patients with OSAS had a much higher prevalence of intracranial aneurysms, after adjusting all possible confounding factors such as age, sex, smoking status, alcohol drinking, and body mass index (odds ratio: 2.32; 95% confidence interval: 1.07-5.04). Additionally, the OSAS group had noticeably larger aneurysms compared with those of the non-OSAS group (3.2 ± 2.0 mm vs. 2.0 ± 0.4 mm, p = 0.013). We found a significant association between OSAS and intracranial aneurysms. OSAS could be another risk factor for the development of intracranial aneurysms.

Keywords: intracranial aneurysm; obstructive sleep apnea; polysomnography.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A flowchart of study participants. MRA: magnetic resonance angiography; MRI: magnetic resonance image; OSAS: obstructive sleep apnea syndrome; PSG: polysomnography.
Figure 2
Figure 2
Maximal diameter measurements of the intracerebral aneurysm (red arrows).
See this image and copyright information in PMC

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