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Review
. 2023 Dec 29;13(1):199.
doi: 10.3390/jcm13010199.

Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis

Nazli Begum Ozturk  1 , Ece Janet Dinc  2 , Abhishek Swami  3 , Ahmet Gurakar  4
Affiliations
Review

Acute Kidney Injury and Hepatorenal Syndrome in Patients with Cirrhosis

Nazli Begum Ozturk et al. J Clin Med. .

Abstract

Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis. Hepatorenal syndrome (HRS) is a type of AKI known as HRS-AKI. It is a severe complication of cirrhosis with high morbidity and mortality. While certain vasoconstrictor medications have been shown to improve HRS-AKI, no clear transplant-free survival benefit has been reported with medical therapies. Patients with HRS-AKI should be considered for urgent liver transplantation evaluation. In this review, we discuss the most recent updates on the definition, diagnosis, and management of AKI in cirrhosis, with special a emphasis on HRS.

Keywords: acute kidney injury; cirrhosis; hepatorenal syndrome; liver disease; terlipressin.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pathophysiology of hepatorenal syndrome. Abbreviations: CO: carbon monoxide, GFR: glomerular filtration rate, IL: interleukin, NO: nitric oxide, PAMPs: pathogen-associated molecular patterns, TNF: tumor necrosis factor.
See this image and copyright information in PMC

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