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Review
. 2024 Jan 3;29(1):256.
doi: 10.3390/molecules29010256.

Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy

Shaozhen Jing  1   2 , Xiaolei Wu  1   2 , Dou Niu  3 , Jing Wang  1   2 , Chung-Hang Leung  3   4   5   6 , Wanhe Wang  1   2
Affiliations
Review

Recent Advances in Organometallic NIR Iridium(III) Complexes for Detection and Therapy

Shaozhen Jing et al. Molecules. .

Abstract

Iridium(III) complexes are emerging as a promising tool in the area of detection and therapy due to their prominent photophysical properties, including higher photostability, tunable phosphorescence emission, long-lasting phosphorescence, and high quantum yields. In recent years, much effort has been devoted to develop novel near-infrared (NIR) iridium(III) complexes to improve signal-to-noise ratio and enhance tissue penetration. In this review, we summarize different classes of organometallic NIR iridium(III) complexes for detection and therapy, including cyclometalated ligand-enabled NIR iridium(III) complexes and NIR-dye-conjugated iridium(III) complexes. Moreover, the prospects and challenges for organometallic NIR iridium(III) complexes for targeted detection and therapy are discussed.

Keywords: NIR; detection; iridium(III) complexes; therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Schematic diagram of application of organometallic NIR iridium(III) complexes.
Figure 2
Figure 2
Two main strategies of designing NIR iridium(III) complexes. (1) Cyclometalated ligand-enabled NIR iridium(III) complexes. (2) NIR dye conjugation-enabled NIR iridium(III) complexes.
Figure 3
Figure 3
Chemical structures of 1–3.
Figure 4
Figure 4
Construction of the multimodal HClO imaging probe. Reproduced with permission from Ref. [66] Copyright 2023 American Chemical Society.
Figure 5
Figure 5
Chemical structures of 4b–5b.
Figure 6
Figure 6
Schematic illustration of the mechanism of 7a response to Cys and Hcy. Red simply represents enhanced luminescence of the complex. Reproduced with permission from Ref. [68]. Copyright 2017 Royal Society of Chemistry.
Figure 7
Figure 7
Chemical structures of 8a–8c.
Figure 8
Figure 8
Chemical structures of 9–12.
Figure 9
Figure 9
Chemical structures of 13–16b.
Figure 10
Figure 10
Chemical structures of 17–19.
Figure 11
Figure 11
Chemical structures of complexes 20a and 20b, and the illustration of cell death pathways induced by 20b. Reproduced with permission from Ref. [84]. Copyright 2021 John Wiley and Sons (Hoboken, NJ, USA).
Figure 12
Figure 12
Chemical structure of 21.
Figure 13
Figure 13
Chemical structures of 22a–23.
Figure 14
Figure 14
Chemical structures of 24a–25b.
Figure 15
Figure 15
Chemical structures of 26a–27a.
Figure 16
Figure 16
Schematic representation of the iridium(III)-coumarin conjugate 27b. Reproduced with permission from Ref. [89]. Copyright 2019 John Wiley and Sons.
Figure 17
Figure 17
Schematic illustration of the working mechanism of iridium(III) complex-derived polymeric micelles for combined PDT and PTT. Reproduced with permission from Ref. [32]. Copyright 2021 John Wiley and Sons.
Figure 18
Figure 18
The structure and anticancer mechanism of 29 for NIR I-type PDT and PTT are depicted schematically. Reproduced with permission from Ref. [108]. Copyright 2020 John Wiley and Sons.
See this image and copyright information in PMC

References

    1. Luan X.W., Pan Y.C., Gao Y.F., Song Y.J. Recent near-infrared light-activated nanomedicine toward precision cancer therapy. J. Mater. Chem. B. 2021;9:7076–7099. doi: 10.1039/D1TB00671A. - DOI - PubMed
    1. Deng Z.Q., Li H.C., Chen S., Wang N., Liu G.Y., Liu D.J., Ou W.H., Xu F.J., Wang X., Lei D.Y., et al. Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner. Nat. Chem. 2023;15:930–939. doi: 10.1038/s41557-023-01242-w. - DOI - PubMed
    1. Grimm J.B., Lavis L.D. Caveat fluorophore: An insiders’ guide to small-molecule fluorescent labels. Nat. Methods. 2022;19:149–158. doi: 10.1038/s41592-021-01338-6. - DOI - PubMed
    1. Kim H.U., Kim T., Kim C., Kim M., Park T. Recent Advances in Structural Design of Efficient Near-Infrared Light-Emitting Organic Small Molecules. Adv. Funct. Mater. 2023;33:2208082. doi: 10.1002/adfm.202208082. - DOI
    1. Martinic I., Eliseeva S.V., Petoud S. Near-infrared emitting probes for biological imaging: Organic fluorophores, quantum dots, fluorescent proteins, lanthanide(III) complexes and nanomaterials. J. Lumin. 2017;189:19–43. doi: 10.1016/j.jlumin.2016.09.058. - DOI

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