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. 2023 Dec 21;25(1):163.
doi: 10.3390/ijms25010163.

The Tumor Necrosis Factor-α Level in Platelet-Rich Plasma Might Be Associated with Treatment Outcome in Patients with Interstitial Cystitis/Bladder Pain Syndrome or Recurrent Urinary Tract Infection

Jia-Fong Jhang  1 , Yuan-Hong Jiang  1 , Teng-Yi Lin  2 , Hann-Chorng Kuo  1
Affiliations

The Tumor Necrosis Factor-α Level in Platelet-Rich Plasma Might Be Associated with Treatment Outcome in Patients with Interstitial Cystitis/Bladder Pain Syndrome or Recurrent Urinary Tract Infection

Jia-Fong Jhang et al. Int J Mol Sci. .

Abstract

Using platelet-rich plasma (PRP) injections to treat urological diseases has attracted great attention. This study investigated the impact of cytokine concentrations in PRP on the treatment outcome of patients with recurrent urinary tract infection (rUTI) and interstitial cystitis/bladder pain syndrome (IC/BPS). Forty patients with IC/BPS and twenty-one patients with rUTI were enrolled for four-monthly repeated PRP injections. PRP was collected at the first injection and analyzed with multiplex immunoassays for 12 target cytokines. In patients with IC/BPS, a Global Response Assessment (GRA) score ≥ 2 was defined as a successful outcome. In rUTI patients, ≤2 episodes of UTI recurrence during one year of follow-up was considered a successful outcome. Nineteen (47.5%) patients with IC/BPS and eleven (52.4%) patients with rUTI had successful outcomes. The IC/BPS patients with successful outcomes had significantly lower levels of tumor necrosis factor-α (TNF-α) in their PRP than those with unsuccessful outcomes (p = 0.041). The rUTI patients with successful outcomes also had a lower level of TNF-α (p = 0.025) and a higher level of epidermal growth factor (p = 0.035) and transforming growth factor-β2 (p = 0.024) in PRP than those with unsuccessful outcomes. A lower level of TNF-α in PRP might be a potentially predictive factor of treatment outcome.

Keywords: biomarkers; inflammation; prognosis; proteins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The level of TNF-α in PRP could be used to predict treatment outcome in patients with IC/BPS or UTI. (A) The ROC curve for using TNF-α level in PRP to predict successful outcomes in IC/BPS patients who underwent PRP injections. AUC = 0.633, cut-off value = 4.82, sensitivity = 0.636, and specificity = 0.643. (B) The ROC curve for using TNF-α level in PRP to predict successful outcome in rUTI patients who underwent PRP injections. AUC = 0.798, cut-off value = 14.54, sensitivity = 0.889, and specificity = 0.727.
Figure 2
Figure 2
The scheme of study process, inclusion and exclusion criteria.
See this image and copyright information in PMC

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References

    1. Alves R., Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Ski. Appendage Disord. 2018;4:18–24. doi: 10.1159/000477353. - DOI - PMC - PubMed
    1. Conde Montero E., Fernandez Santos M.E., Suarez Fernandez R. Platelet-rich plasma: Applications in dermatology. Actas Dermosifiliogr. 2015;106:104–111. doi: 10.1016/j.ad.2013.12.021. - DOI - PubMed
    1. Chellini F., Tani A., Zecchi-Orlandini S., Sassoli C. Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration. Int. J. Mol. Sci. 2019;20:683. doi: 10.3390/ijms20030683. - DOI - PMC - PubMed
    1. Bertrand-Duchesne M.P., Grenier D., Gagnon G. Epidermal growth factor released from platelet-rich plasma promotes endothelial cell proliferation in vitro. J. Periodontal. Res. 2010;45:87–93. doi: 10.1111/j.1600-0765.2009.01205.x. - DOI - PubMed
    1. Lim W., Park S.H., Kim B., Kang S.W., Lee J.W., Moon Y.L. Relationship of cytokine levels and clinical effect on platelet-rich plasma-treated lateral epicondylitis. J. Orthop. Res. 2018;36:913–920. doi: 10.1002/jor.23714. - DOI - PubMed