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Review
. 2023 Dec 25;25(1):296.
doi: 10.3390/ijms25010296.

Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer

Vanessa-Meletia Bala  1 , Dimitra Ioanna Lampropoulou  2 , Stamatiki Grammatikaki  3 , Vassilios Kouloulias  4 , Nefeli Lagopati  3 , Gerasimos Aravantinos  5 , Maria Gazouli  3
Affiliations
Review

Nanoparticle-Mediated Hyperthermia and Cytotoxicity Mechanisms in Cancer

Vanessa-Meletia Bala et al. Int J Mol Sci. .

Abstract

Hyperthermia has the potential to damage cancerous tissue by increasing the body temperature. However, targeting cancer cells whilst protecting the surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that the combination of nanotechnology and hyperthermia offers more successful penetration of nanoparticles in the tumor environment, thus allowing targeted hyperthermia in the region of interest. At the same time, unlike radiotherapy, the use of non-ionizing radiation makes hyperthermia an attractive therapeutic option. This review summarizes the existing literature regarding the use of hyperthermia and nanoparticles in cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.

Keywords: cancer; cytotoxicity mechanisms; hyperthermia; nanoparticles.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Nanoparticle-mediated, cancer-related hyperthermia mechanisms.
See this image and copyright information in PMC

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