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Case Reports
. 2023 Nov 12:28:102141.
doi: 10.1016/j.jaccas.2023.102141. eCollection 2023 Dec 20.

Chemotherapy in Pregnancy: Assessing the Safety of Adriamycin Administration in Pregnancy Complicated by Breast Cancer

Priyanshu Nain  1 , Lakshya Seth  2 , Ashley Shawn Bell  1 , Priyanka Raval  3 , Gyanendra Sharma  4 , Monique Bethel  4 , Garima Sharma  5 , Avirup Guha  1   4
Affiliations
Case Reports

Chemotherapy in Pregnancy: Assessing the Safety of Adriamycin Administration in Pregnancy Complicated by Breast Cancer

Priyanshu Nain et al. JACC Case Rep. .

Abstract

Pregnancy-associated breast cancer is challenging to treat. Treatment with chemotherapeutic agents such as anthracyclines poses a risk of cardiotoxicity, despite being considered safe after the second trimester of pregnancy. Management requires multidisciplinary comanagement with cardio-obstetrics, cardiology-oncology, maternal-fetal medicine, and oncology.

Keywords: cancer; cardiomyopathy; pregnancy.

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Conflict of interest statement

Dr Guha is supported by the American Heart Association–Strategically Focused Research Network Grant in Disparities in Cardio-Oncology (#847740 and #863620) and the Department of Defense Prostate Cancer Research Program Physician Research Award #HT9425-23-1-0158; and has consulted for Myovant, Pfizer, and Novartis. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Patient With PABC (A) Echocardiogram (quality – average – contrast not used due to pregnancy) of a patient with PABC planning anthracycline-based treatment; (B) electrocardiogram of the same patient at the cardio-oncology clinic visit; (C) curved planar reconstructions of all 3 coronaries and 3-dimensional reconstruction of the coronary tree of the same patient obtained using a computed tomographic angiogram after pregnancy; (D) cardiac magnetic resonance single-shot steady-state free precession image of late gadolinium enhancement – 3-chamber view. PABC = pregnancy-associated breast cancer.
See this image and copyright information in PMC

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