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. 2023 Sep 4:15:165-169.
doi: 10.1016/j.ibneur.2023.08.2194. eCollection 2023 Dec.

The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

Shihao Wu  1   2 , Xiaoli Liu  3 , Haiyan Yang  1   4 , Wenlin Ma  2   5 , Zhao Qin  1   4
Affiliations

The effect of lipid metabolism on age-associated cognitive decline: Lessons learned from model organisms and human

Shihao Wu et al. IBRO Neurosci Rep. .

Abstract

Lipids are required as integral building blocks of cells to support cellular structures and functions. The intricate mechanisms underpinning lipid homeostasis are essential for the health and maintenance of the central nervous system. Here we summarize the recent advances in dissecting the effect of lipid metabolism on cognitive function and its age-associated decline by reviewing relevant studies ranging from invertebrate model organisms to mammals including human.

Keywords: Age-associated cognitive decline; Human; Lipid metabolism; Model organisms.

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Fig. 1
Fig. 1
Recent findings in understanding the role of lipid metabolism in regulating age-associated cognitive decline from both model organisms and human.
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