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Editorial
. 2023 Dec 26;12(12):2565-2569.
doi: 10.21037/tlcr-23-665. Epub 2023 Dec 20.

Can liquid biopsy dynamics stratify patients with small cell lung cancer?

Christoffer T Maansson  1   2 , Peter Meldgaard  3 , Boe Sandahl Sorensen  1   2
Affiliations
Editorial

Can liquid biopsy dynamics stratify patients with small cell lung cancer?

Christoffer T Maansson et al. Transl Lung Cancer Res. .
No abstract available

Keywords: Small cell lung cancer (SCLC); aneuploidy; circulating tumor DNA (ctDNA); liquid biopsy; next-generation sequencing (NGS).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-23-665/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Experimental setup made by Sivapalan et al. (created with BioRender.com). BL, baseline; ICI, immune checkpoint inhibitor; cfDNA, cell-free DNA; PBMC, peripheral blood mononuclear cells; TEC-seq, targeted error-correction sequencing; cfTL, cell-free tumor load; CNA, copy-number alteration; indel, insertion/deletion; SNV, single-nucleotide variant.
Figure 2
Figure 2
Molecular analysis and key findings by Sivapalan et al. (created with BioRender.com). Three illustrative examples of different cfTL dynamics observed with liquid biopsies. The dashed line indicates the detection limit for cfTL and vertical ticks indicate different blood samples. cfTL, cell-free tumor load; BL, baseline; OS, overall survival; PFS, progression-free survival; CH, clonal hematopoiesis; cfDNA, cell-free DNA; PBMC, peripheral blood mononuclear cell; CNA, copy-number alteration.
See this image and copyright information in PMC

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References

    1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660 - DOI - PubMed
    1. American Cancer Society. Facts & Figures 2023. American Cancer Society. 2023.
    1. Zugazagoitia J, Paz-Ares L. Extensive-Stage Small-Cell Lung Cancer: First-Line and Second-Line Treatment Options. J Clin Oncol 2022;40:671-80. 10.1200/JCO.21.01881 - DOI - PubMed
    1. Zhang S, Cheng Y. Immunotherapy for extensive-stage small-cell lung cancer: current landscape and future perspectives. Front Oncol 2023;13:1142081. 10.3389/fonc.2023.1142081 - DOI - PMC - PubMed
    1. Arriola E, Trigo JM, Sánchez-Gastaldo A, et al. Prognostic Value of Clinical Staging According to TNM in Patients With SCLC: A Real-World Surveillance Epidemiology and End-Results Database Analysis. JTO Clin Res Rep 2021;3:100266. 10.1016/j.jtocrr.2021.100266 - DOI - PMC - PubMed