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. 2023 Dec 10;10(1):e23474.
doi: 10.1016/j.heliyon.2023.e23474. eCollection 2024 Jan 15.

Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration

Bo Li  1   2 , Chang Lu  1   2 , Yibo Liu  1   2 , Xiaodong Wang  1   2 , Haiqi Fu  1   2 , Changyi Li  1   2 , Mingjuan Sun  1   2 , Yajun Zhang  1   2 , Minhui Li  1   2
Affiliations

Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration

Bo Li et al. Heliyon. .

Abstract

Background: Hypertension has become a part of the lives of many people worldwide. With the development, an increasing number of people have begun to control their hypertension through products of medicine food homology, such as Buyang Huanwu Decoction (BYHWD). However, there has been no objective review of the regulation of hypertension by BYHWD.

Methods: As of 9 October 2023, this review made a detailed search of nine databases to look for random controlled trials (RCTs) focused on the use of BYHWD for treating hypertension. This was followed by network pharmacological analysis, and molecular docking assessment using AutoDockTools to explore the mode of action.

Results: BYHWD was effective in reducing SBP (MD: 0.767; 95 % CI: 0.629, 0.905; p = 0.000), DBP (MD: 0.427; 95 % CI: 0.292, 0.561; p = 0.000), 24h SBP (MD: 0.665; 95 % CI: 0.368, 0.962; p = 0.000), 24h DBP (MD: 0.547; 95 % CI: 0.318, 0.777; p = 0.000), dSBP (MD: 0.625; 95 % CI: 0.395, 0.855; p = 0.000), dDBP (MD: 0.632; 95 % CI: 0.401, 0.862; p = 0.000), nSBP (MD: 0.859; 95 % CI: 0.340, 1.377; p = 0.001), nDBP (MD: 0.704; 95 % CI: 0.297, 1.112; p = 0.001), pv (MD: 1.311; 95 % CI: 0.363, 2.259; p = 0.007) and NIHSS (MD: 1.149; 95 % CI: 0.100, 2.199; p = 0.032), and elevating CER (OR = 2.848; 95 % CI: 1.388, 5.843; p = 0.004). However, BYHWD did not significantly reduce HCY, and there was no significant difference in the incidence of AE. In terms of the mechanism of action, the main active ingredient of BYHWD is quercetin, and the core targets are AKT1, MMP9, and others. Molecular docking also showed that quercetin mainly interacts with the amino acid residue CYS-28 of MMP2. Second, the KEGG analysis showed that BYHWD mainly act on HIF-1, Apelin, and cGMP-PKG signalling pathways, and GO analysis showed that it related to the apical part of the cell, circulatory system processes, and nuclear receptor activity. Conclusion: BYHWD can lowered blood pressure, reduced plasma viscosity, and restored neurological function with good tolerability, and had no significant effect on HCY levels. This study further demonstrated that quercetin is the main active ingredient of BYHWD that acts via the AKT1 and HIF-1 signalling pathways. These results provide new guidance for people's dietary choices by the general public.

Keywords: BYHWD; Hypertension; Medicine food homology; Meta; Molecular docking; Network pharmacology.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yajun Zhang reports financial support was provided by Inner Mongolia Medical University. Yajun Zhang reports a relationship with Inner Mongolia Medical University that includes: employment. No other influencing factors. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
a. The proportions of various ingredients in BYHWD. Earthworm Chinese Angelica Radix Paeonia Rubra Safflower, Astragalus Membranaceus Peach Kernel Rhizoma Chuanxiong, Fig. 1b. Photographs showing the natural ingredients of BYHWD.
Fig. 2
Fig. 2
Flowchart of the study selection process.
Fig. 3
Fig. 3
a Overall Risk of Bias, Fig. 3 b. Risk of Bias Bar Chart.
Fig. 4
Fig. 4
Forest plot meta-Aanalysis results for SBP.
Fig. 5
Fig. 5
Forest plot meta-analysis results for DBP.
Fig. 6
Fig. 6
Forest plot meta-analysis results for CER, HCY, PV, NIHSS, and AE.
Fig. 7
Fig. 7
Subgroup and sensitivity analysis of SBP.
Fig. 8
Fig. 8
Subgroup and sensitivity analysis for DBP
Fig. 9
Fig. 9
Subgroup and sensitivity analysis for CER, HCY, PV, NIHSS.
Fig. 10
Fig. 10
TSA
Fig. 11
Fig. 11
Publication bias analysis.
Fig. 12
Fig. 12
Key gene target screening and protein interaction analysis.
Fig. 13
Fig. 13
GO and KEGG enrichment analysis.
Fig. 14
Fig. 14
Effective Active Compound-Target Network of BYHWD Drawing note.
Fig. 15
Fig. 15
Schematic showing the docking of MMP2 and Quercetin.
See this image and copyright information in PMC

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References

    1. Franco C., et al. Essential hypertension and oxidative stress: novel future perspectives. Int. J. Mol. Sci. 2022;23(22) - PMC - PubMed
    1. Yin R., et al. Hypertension in China: burdens, guidelines and policy responses: a state-of-the-art review. J. Hum. Hypertens. 2022;36(2):126–134. - PMC - PubMed
    1. Zhou X.L., et al. [Clinical research of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension] Zhen Ci Yan Jiu. 2022;47(2):165–170. - PubMed
    1. Gong X., et al. Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China. Crit. Rev. Food Sci. Nutr. 2020;60(14):2303–2326. - PubMed
    1. Tang X., et al. Development and application of one root of medicine and food. Modern Chinese Medicine. 2020;22(9):1428–1433.